用于软骨下骨修复的镁基支架

Magnesium-based scaffolds for subchondral bone regeneration

骨关节炎(osteoarthritis,OA)作为一种可以导致残疾的退行性疾病,常累及软骨下骨。受损的关节软骨和软骨下骨很难自愈,用于功能修复的组织工程支架是一种有前途的治疗方法。近年来,镁合金因其良好的机械和生物学性能被视为可降解多孔支架有希望的候选者。然而,目前对于适用于软骨下骨缺损修复的镁基支架的结构设计和优化方案还没有定论。归纳了镁合金用于骨软骨支架的研究进展,包括多孔支架的制造方法;添加合金元素和表面改性的优化策略;参数化与非参数化的结构设计;镁基支架的机械、降解和生物学性能及其影响因素。讨论了未来研究的潜在方向。旨在为多孔镁基支架的开发和临床应用提供参考。

Osteoarthritis(osteoarthritis,OA)is a degenerative disease that can lead to disability,often affecting subchondral bone.Damaged articular cartilage and subchondral bone remain challenging to heal independently,and scaffolds for tissue regeneration are a promising therapeutic method.Recently,Magnesium alloys have been considered as promising candidates for biodegradable porous scaffolds due to their good mechanical and biological properties.However,there is still no consensus on the structural design and optimization of magnesium-based scaffolds suitable for subchondral bone regeneration.Therefore,this review summarizes the research progress of magnesium alloys used for osteochondral scaffolds,including fabrication methods of porous scaffolds,optimization strategies involving alloying elements and surface modifications,parametric and non-parametric structural design,degradation,mechanical and biological properties of magnesium-based scaffolds and their influencing factors.Also,this paper discussed the potential directions of future research,intending to provide references for the development and clinical applications of porous magnesium-based scaffolds.