狼疮肾炎生物标志物的研究进展

Advances in biomarkers of lupus nephritis

狼疮性肾炎是系统性红斑狼疮最常见最严重的临床表现,是发病和死亡的最常见原因。狼疮性肾炎的免疫抑制治疗可能对肾脏产生不利影响,并导致慢性肾功能衰竭的发生,从而增加发病率和死亡率。生物标记物在早期诊断、评估疾病活动性和反映SLE干预措施的治疗效果方面发挥着至关重要的作用。研究活动性狼疮肾炎的相关标志物,对早期诊断、评估疾病进程、指导临床治疗方面有重要的临床意义。

Lupus nephritis is the most common and severe clinical manifestation of systemic lupus erythematosus,which is the most common cause of morbidity and mortality.Immunosuppressive therapy to Lupus nephritis may adversely affect the kidneys and lead to chronic kidney failure,which may increase morbidity and mortality.Biomarkers play a crucial role in early diagnosis,assessment of disease activity and evaluation of therapeutic efficacy of SLE interventions.It has important clinical significance to study the markers of active lupus nephritis in early diagnosis,evaluation of disease process and guidance of clinical treatment.