血细胞计数指标在冠心病患者临床诊疗中的研究进展

Research progress of complete blood count in clinical diagnosis and treatment of coronary heart disease

冠状动脉粥样硬化性心脏病(冠心病)(coronary heart disease,CHD)是临床上常见的疾病,严重危害人类健康。目前许多生物标志物已经被作为冠心病的发生、发展和总体预后的预测因子进行研究。其中,鉴于血细胞计数指标相对便宜且易于衍生以及动脉粥样硬化过程的炎症性质,从病理生理学角度以及临床和公共卫生影响来看,在冠心病研究中证明全身炎症的血细胞计数指标的阳性结果可能很有意义。该文就常见的血细胞计数指标,如平均血小板体积(mean platelet volume,MPV)、红细胞分布宽度(red cell distribution width,RDW)、中性粒细胞/淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、单核细胞/淋巴细胞比值(monocyte to lymphocyte ratio,MLR)和血小板/淋巴细胞比值(platelet to lymphocyte ratio,PLR)在冠心病诊断和预后中的作用及其潜在的临床应用进行综述。

Coronary heart disease(CHD)is a common disease that seriously endangers human health.Many biomarkers have been studied as predictors of the occurrence,progression and overall prognosis of CHD.The complete blood count(CBC)is a cheap examination,and CBC indexes are contributed to reflect the inflammatory response during the process of atherosclerosis.From the pathophysiological,clinical and public health perspectives,positive findings in the CBC that reflect the systemic inflammation are of great significance to CHD.This review describes the role and potential clinical application of common CBC indicators,such as the mean platelet volume(MPV),red cell distribution width(RDW),neutrophil-to-lymphocyte ratio(NLR),monocyte-to-lymphocyte ratio(MLR),and platelet-to-lymphocyte ratio(PLR)in the diagnosis and prognosis of CHD.