奥曲肽辅助特利加压素治疗肝硬化失代偿期并发上消化道出血的临床效果观察

Clinical Effect Observation of Octreotide Combined with Terlipressin in Treatment of Upper Gastrointestinal Bleeding Complicated with Decompensated Cirrhosis

目的探究在肝硬化失代偿期并发上消化道出血的治疗中采用奥曲肽辅助特利加压素治疗的临床价值。方法选取2021年1—12月本院收治的80例肝硬化失代偿期并发上消化道出血患者为研究对象,根据随机分组法分成对照组(特利加压素)和观察组(奥曲肽辅助特利加压素),对比两组的治疗效果。结果治疗后,观察组的总胆红素水平低于对照组(P<0.05),白蛋白水平高于对照组(P<0.05)。两组治疗后的直接胆红素水平无明显区别(P>0.05)。观察组治疗后的门静脉血流量、脾静脉血流量均低于对照组(P<0.05)。观察组总治疗率高于对照组(P<0.05)。观察组出血量低于对照组(P<0.05),住院时间以及止血时间均短于对照组(P<0.05)。结论在肝硬化失代偿期并发上消化道出血的治疗中,在应用特利加压素治疗的标准上辅助使用奥曲肽进行治疗,能够促进患者的肝功能有所改善,快速止血,促进病情的好转,临床有效性高。

Objective To explore clinical value of octreotide and terlipressin in treatment of upper gastrointestinal bleeding complicated with decompensated cirrhosis.Methods Screening time of subjects was from January 2021 to December 2021,the paper divided 80 patients with decompensated cirrhosis complicated with upper gastrointestinal bleeding into two groups randomly,control group(with terlipressin)and observation group(with octreotide plus terlipressin).Treatment effect between two groups was compared.Results After treatment,total bilirubin level of observation group was lower than control group(P<0.05),albumin level was higher than control group(P<0.05).There was no significant difference in direct bilirubin level between two groups after treatment(P>0.05).Portal vein blood flow and splenic vein blood flow in observation group after treatment was lower than control group(P<0.05).Total treatment rate of observation group was higher than control group(P<0.05).Bleeding volume in observation group was lower than control group(P<0.05),hospital stay and hemostasis time was shorter than control group(P<0.05).Conclusion Auxiliary treatment of octreotide based on terlipressin treatment can improve liver function,stop bleeding quickly,improve condition with high clinical effect in treatment of decompensated cirrhosis complicated with upper gastrointestinal bleeding.