幽门螺杆菌感染患者采用阿莫西林与呋喃唑酮四联疗法治疗的效果

Effect of Amoxicillin and Furazolidone Quadruple Therapy on Patients with Helicobacter Pylori Infection

目的研究阿莫西林与呋喃唑酮的四联疗法治疗幽门螺杆菌(Hp)感染患者的疗效。方法选取2020年1月—2022年12月本院消化内科收治的Hp感染患者100例为研究对象,以随机数字表法分入两组中,对照组应用甲硝唑联合呋喃唑酮治疗,观察组应用阿莫西林、呋喃唑酮、雷贝拉唑、胶体果胶铋四联疗法治疗,均治疗14天,对比两组的Hp根除率、不良反应发生率等。结果观察组的Hp根除率高于对照组,组间差异有统计学意义(P<0.05);观察组治疗后的临床症状评分显著低于对照组,组间差异有统计学意义(P<0.05);观察组治疗后的血浆Gas-17水平明显低于对照组,组间差异有统计学意义(P<0.05);组间不良反应发生率差异不具有统计学意义(P>0.05)。结论含有阿莫西林与呋喃唑酮的四联疗法在Hp感染治疗中疗效肯定,有助于促进Hp根除,减少胃酸分泌,有助于增强胃黏膜防御功能,值得推广。

Objective To study effect of amoxicillin and furazolidone quadruple therapy in treatment of helicobacter pylori(Hp)infection.Methods The paper chose 100 patients with Helicobacter pylori infection in gastroenterology department of our hospital from January 2020 to December 2022 as study subjects,and divided them into two groups randomly with digital table method.Control group was treated with metronidazole combined with furazolidone,and observation group with amoxicillin,furazolidone,rabeprazole and colloidal bismuth pectin,all cases were treated for 14 days.Eradication rate of Hp and incidence of adverse reactions was compared between two groups.Results Hp eradication rate of 96.00% in observation group was higher than 82.00% in control group(P<0.05).Clinical symptom scores of observation group after treatment were significantly lower than control group(P<0.05).The plasma Gas-17 levels in observation group after treatment were significantly lower than control group(P<0.05).There was no statistically significant difference in adverse reactions incidence between groups(P>0.05).Conclusion Amoxicillin and furazolidone quadruple therapy can achieve positive effect in treatment of Helicobacter pylori infection,can promote eradication of Hp,reduce secretion of gastric acid,and enhance defense function of gastric mucosa,which is worthy of promotion.