布地奈德雾化吸入治疗小儿急性喉炎的临床疗效

Clinical Effect of Budesonide Aerosol Inhalation for Children with Acute Laryngitis

目的探讨小儿急性喉炎布地奈德雾化吸入治疗的疗效。方法回顾性选取2020年1月—2022年12月重庆金童佳儿童医院小儿急性喉炎患儿60例,依据治疗方法分为布地奈德雾化吸入治疗组(布地奈德组)、地塞米松雾化吸入治疗组(地塞米松组)两组,每组各30例。统计分析两组症状评分、炎症因子水平、心理状态、临床疗效、症状消失时间、不良反应发生情况、家长满意度。结果布地奈德组犬吠样咳嗽、喉鸣、声嘶、呼吸困难评分、IL-4、IL-8水平、焦虑、抑郁评分均低于地塞米松组(P<0.05)。布地奈德组总有效率优于地塞米松组(χ2=5.192,P<0.05)。布地奈德组犬吠样咳嗽消失时间、喉鸣消失时间、声嘶消失时间、呼吸困难消失时间短于地塞米松组(P<0.05)。布地奈德组不良反应发生率低于地塞米松组(χ2=4.320,P<0.05)。布地奈德组家长满意度优于地塞米松组(χ2=6.667,P<0.05)。结论小儿急性喉炎布地奈德雾化吸入治疗的临床疗效较地塞米松雾化吸入治疗显著。

Objective To investigate effect of aerosol inhalation of budesonide in treatment of acute laryngitis of children.Methods The paper reviewed and chose 60 children with acute laryngitis in children's otorhinolaryngology department of our hospital from January 2020 to December 2022,and divided them into two groups according to treatment method:budesonide aerosol inhalation treatment group(budesonide group)and dexamethasone aerosol inhalation treatment group(dexamethasone group),with 30 cases in each group.Symptom scores,levels of inflammatory factors,psychological status,clinical effect,time of symptom disappearance,incidence of adverse reactions,and parental satisfaction degree were statistically analyzed between two groups.Results Budesonide group was lower than dexamethasone group in barking cough,laryngeal ringing,hoarseness,dyspnea scores,IL-4,IL-8 levels,anxiety and depression scores(P<0.05).Total effective rate of budesonide group was better than dexamethasone group(χ2=5.192,P<0.05).Disappearance time of barking cough,laryngeal ringing,hoarseness and dyspnea in budesonide group was shorter than dexamethasone group(P<0.05).Incidence of adverse reactions was lower than dexamethasone group(χ2=4.320,P<0.05).Satisfaction degree of parents in budesonide group was better than dexamethasone group(χ2=6.667,P<0.05).Conclusion Budesonide aerosol inhalation can achieve significantly better clinical effect in treatment of acute laryngitis of children than dexamethasone aerosol inhalation.