PP1A在肿瘤发生发展过程中的作用及研究进展

Role of PP1A in cancer and research progress

蛋白磷酸酶是一组在人类细胞中广泛存在并催化已经磷酸化的蛋白质分子发生去磷酸化反应的一类酶分子。而磷酸蛋白磷酸酶催化亚基超家族是一组主要使丝氨酸/苏氨酸残基去磷酸化的蛋白磷酸酶,其中蛋白磷酸酶1(protein phosphatase-1,PP1)参与了真核生物大部分的去磷酸化反应,并参与调节多种生物活动。由PPP1CA基因编码的PP1催化亚基α(catalytic subunit alpha of protein phosphatase-1,PP1A)是修饰PP1最重要的一种亚型,在多种肿瘤生存和转移中起着重要作用,但其在肿瘤中也会表现出抑制作用,这使其可能成为肿瘤治疗的新靶标。因此,本文旨在对PP1A在多种肿瘤中关键作用进行综述,并针对其作为肿瘤治疗的新靶标潜力进行评价。

Protein phosphatases are a group of proteins that widely exist in human cells and catalyze protein dephosphorylation.The phosphoprotein phosphatase catalytic subunits(PPPCs)superfamily is a group of protein phosphatases that primarily dephosphorylate serine/threonine residues.The protein phosphatase-1(PP1)is involved in most eukaryotic phosphorylation reaction and participates in regulating a variety of biological activities.The catalytic subunit α of PP1(PP1A)is the most important subtype of the PP1 catalytic subunit encoded by PPP1CA,which plays an important role in the survival and metastasis of a variety of tumors,but it also exhibits inhibitory effect in tumors,which makes it a possible new target for tumor treatment.Therefore,this article aims to review the key role of PP1A in a variety of tumors and evaluate its potential as a novel target for tumor therapy.