基于功能磁共振成像技术的颈椎病中枢重塑机制研究进展

Research progress on the mechanism of central remodeling of cervical spondylosis based on functional magnetic resonance imaging

颈椎病(cervical spondylosis,CS)是在颈部退变基础上引起颈椎周围组织结构和功能改变而产生的一系列临床综合征,患者的身心健康和生活质量常受到严重影响,既往研究多关注CS躯体功能障碍,忽视了中枢可塑性在该病发生发展中的重要性。功能磁共振成像(functional magnetic resonance imaging,fMRI)技术的推广应用则为CS中枢重塑和临床疗效提供了可视化的证据。本文通过查阅近年来国内外关于CS中枢功能改变的文献并进行综述,结果发现研究主要集中在CS慢性脊髓压迫、CS慢性颈痛和颈性眩晕等方向,患者多表现出脑区的异常神经元活动、功能连接改变和脑网络的改变;同时,本文提出了当前研究不足及发展方向,以期为未来CS的诊断、治疗、预后提供更多的神经影像学参考和借鉴。

Cervical spondylosis(CS)is a series of clinical syndromes caused by changes in the structure and function of the tissues around the cervical spine on the basis of neck degeneration,and the physical and mental health and quality of life of patients are often seriously affected.The popularization of functional magnetic resonance imaging(fMRI)provides visual evidence for CS central lesions and clinical efficacy.By reviewing the literature on CS central function changes at home and abroad in recent years,and reviewing them,we finds that the research mainly focuses on chronic spinal cord compression in cervical spondylosis,chronic neck pain and cervical vertigo,and patients mostly show abnormal neuronal activity,functional connection changes and brain network changes in brain regions,and put forward the current research shortcomings and development directions,in order to provide more neuroimaging references for the diagnosis,treatment and prognosis of CS in the future.