乙醇和丙二醇单用与联用对曲安奈德喷雾溶液透皮性能的影响

Effects of ethanol and propylene glycol alone or in combination on the transdermal properties of triamcinolone acetonide spray solution

目的 对曲安奈德喷雾溶液进行体外透皮试验,考察乙醇和丙二醇单用与联用时对曲安奈德喷雾溶液体外透皮功能的影响。方法 选取新西兰白兔腹部皮肤,用Franz扩散池法对曲安奈德喷雾溶液进行体外透皮试验,用高效液相色谱法(HPLC)测定曲安奈德含量,用单因素方差分析法对各组间的透皮吸收速率进行对比分析。结果 乙醇和丙二醇联用时的透皮吸收速率均显著高于单用时的透皮吸收速率(P<0.05),且乙醇和丙二醇联用时对曲安奈德喷雾溶液的促透作用顺序为10%乙醇+25%丙二醇>10%乙醇+20%丙二醇>15%乙醇+25%丙二醇>15%乙醇+20%丙二醇。结论 10%乙醇和25%丙二醇联用时可使曲安奈德喷雾溶液的透皮功能达到最佳化。

Objective To conduct in vitro transdermal test on triamcinolone acetonide spray solution,and investigate the effects of ethanol and propylene glycol alone or in combination on the in vitro transdermal function of triamcinolone acetonide spray solution.Methods Rabbit abdominal skin was selected,and the in vitro penetration test of triamcinolone acetonide spray solution was carried out by Franz diffusion cell method,and the content of triamcinolone acetonide was determined by HPLC.The rate of transdermal absorption was compared.Results The transdermal absorption rate of the combined use of ethanol and propylene glycol was significantly higher than that of the single use(P<0.05),and the order of promoting the penetration of triamcinolone acetonide spray solution when ethanol and propylene glycol were combined by 10%ethanol+25%propylene glycol>10%ethanol+20%propylene glycol>15%ethanol+25%propylene glycol>15%ethanol+20%propylene glycol.Conclusion The combination of 10%ethanol and 25%propylene glycol could optimize the transdermal function of triamcinolone acetonide spray solution.