基于数据挖掘的中医药治疗TACE术后栓塞综合征用药规律研究

Study on the regularity of traditional Chinese medicine in treatment of postembolization syndrome after TACE based on data mining

目的 探究中医药治疗TACE术后栓塞综合征的用药规律。方法 以《中国知网数据库》(中国知网)、《中国学术期刊数据库》(万方)、《中文科技期刊数据库》(维普)作为数据来源,检索2000年1月至2021年12月与中医药治疗相关的期刊文献,筛选出相关中药复方或中成药制剂,将其所含中药录入Excel 2019表数据库中,并采用SPSS Statistics 21.0和SPSS Modeler 18.0统计软件对数据进行分析。结果 纳入符合标准的方剂86首,共含中药181味,频数共计942次。在纳入的181味中药中,频率≥10%的中药共28种,频数共587次;频数最高的5味中药依次是甘草、茯苓、白术、柴胡和黄芪;功效分类中,以补虚药、清热药和利水渗湿药最为常用;药性药味中,药性前3位依次为温、平、寒,药味前3位依次为甘、苦、辛;归经分类中,归经前3位依次为脾经、肺经和肝经;关联规则分析中得到30条关联规则,因子分析共得到11个公因子,聚类分析得到6个聚类组合,综合得到4个常用药物组合。结论 治疗TACE术后栓塞综合征的处方用药主要为补虚药、清热药和利水渗湿药,治法以健脾益气、清热利湿解毒为主。

Objective To explore the regularity of traditional Chinese medicine(TCM)in the treatment of postembolization syndrome(PES)after transcatheter arterial chemoembolization(TACE).Methods CNKI,WANFANG and VIP were used as data sources to search the journals and literatures related to TCM treatment from January 2000 to December 2021.Then,relevant TCM formula or Chinese patent medicines preparations were screened out.The Chinese medicinal materials contained were entered into Excel 2019 table database,and the data were analyzed by SPSS Statistics 21.0 and SPSS Modeler 18.0 statistical software.Results 86 qualified prescriptions were included,containing 181 Chinese medicinal materials,with a total frequency of 942 times.Of the 181 Chinese herbs included,there were 28 herbs with frequency≥10%,with a total frequency of 587.The top 5 Chinese medicinal materials of frequency were licorice,Poria,Atractylodes,Bupleurum and Astragalus.Among the efficacy classifications,tonifying deficiency drugs,heat-clearing drugs and diuretics were most used.In four properties and five tastes,the top three of four properties were warm,flat and cold,and the top three of five tastes were sweet,bitter and pungent.In the classification of meridians,the first three meridians were spleen meridian,lung meridian and liver meridian.30 association rules were obtained in association rules analysis,11 common factors were obtained by factor analysis,6 clustering combinations were obtained by cluster analysis,and 4 commonly used drug combinations were obtained.Conclusion The prescription drugs for the treatment of PES after TACE were mainly tonic drugs,heat-clearing drugs and diuresis and dampness-draining drugs.The treatment methods were mainly invigorating spleen and replenishing qi,clearing heat and dampness and detoxification.