原发性肝癌综合性介入治疗疗效评价

Evaluation of Comprehensive Interventional Therapy for Primary Liver Cancer

目的评价原发性肝癌(hepatic cell carcinoma,HCC)综合性介入治疗的疗效。方法回顾性分析2021年9月—2022年12月在沛县人民医院就诊的50例HCC患者的临床资料,依据治疗方法的不同将其分为经导管肝动脉化疗栓塞术(transcatheter arterial chemoembolization,TACE)组(n=26)和TACE联合微波消融(mi-crowave ablation,MWA)组(TACE+MWA组,n=24),比较两组术后1个月的近期疗效、临床指标以及术后并发症发生情况的差异性。结果两组术后1个月的疾病控制率分别为69.23%和91.67%,TACE+MWA组较TACE组更高,差异有统计学意义(χ^(2)=3.926,P<0.05)。TACE+MWA组的肝功能Child-Pugh降级、瘤内血流信号消失、瘤周血流信号消失以及甲胎蛋白转阴发生率均较TACE组更高,差异有统计学意义(P<0.05)。两组患者术后肝区疼痛、低热以及恶心纳差的发生率比较,差异无统计学意义(P>0.05)。结论与单一TACE治疗相比,TACE+MWA综合性介入治疗HCC效果显著,可有效改善患者临床症状,较为安全。

Objective To evaluate the efficacy of comprehensive interventional therapy for primary liver cancer(hepatic cell carcinoma,HCC).Methods The clinical data of 50 HCC patients treated in Peixian People's Hospital from September 2021 to December 2022 were retrospectively analyzed.According to the different treatment methods,they were divided into transcatheter arterial chemoembolization(TACE)group(n=26)and TACE combined with microwave ablation(TACE+MWA)group(n=24).The short-term efficacy,clinical indicators and postoperative complications were compared between the two groups one month after operation.Results The disease control rate of TACE+MWA group was significantly higher than that of TACE group(69.23%vs 91.67%),and the differences were statistically significant(χ^(2)=3.926,P<0.05).The incidences of Child-Pugh downgrade,intratumoral blood flow signal disappearance,peritumoral blood flow signal disappearance and alpha fetoprotein negative conversion in TACE+MWA group were higher than those in TACE group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of postoperative pain in the hepatic region,low fever,nausea and anorexia between the two groups(P>0.05).Conclusion Compared with single TACE treatment,TACE+MWA comprehensive interventional treatment of HCC has significant effect,can effectively improve the clinical symptoms,which is safe.