经腹子宫肌瘤剔除术联合米非司酮、桂枝茯苓胶囊治疗子宫肌瘤的效果及对生长因子水平的影响

Effect of transabdominal myomectomy combined with mifepristone and Guizhi Fuling capsule in the treatment of uterine fibroids and its influence on growth factors levels

目的探讨经腹子宫肌瘤剔除术联合米非司酮、桂枝茯苓胶囊治疗子宫肌瘤的效果及对生长因子水平的影响。方法选择2019年4月至2022年4月收治的120例子宫肌瘤患者为研究对象,按照随机数字表法将其分为对照组与观察组,各60例。两组均给予经腹子宫肌瘤剔除术,对照组术后给予米非司酮治疗,观察组术后给予米非司酮联合桂枝茯苓胶囊治疗。比较两组的治疗效果。结果观察组的治疗总有效率明显高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的转化生长因子-β1(TGF-β1)、表皮生长因子(EGF)、缺氧诱导因子-1α(HIF-1α)水平低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的微血管密度、血管内皮生长因子(VEGF)水平低于对照组,差异具有统计学意义(P<0.05)。治疗后6、12个月,观察组的复发率低于对照组,差异具有统计学意义(P<0.05)。结论经腹子宫肌瘤剔除术联合米非司酮、桂枝茯苓胶囊治疗子宫肌瘤效果满意,可有效抑制生长因子水平,减少新生血管生成,降低复发率,值得推广。

Objective To explore the effect of transabdominal myomectomy combined with mifepristone and Guizhi Fuling capsule in the treatment of uterine fibroids and its influence on growth factors levels.Methods A total of 120 patients with uterine fibroids admitted from April 2019 to April 2022 were selected as the research objects and divided into control group and observation group according to the random number table method,with 60 cases in each group.Both groups were given transabdominal myomectomy.The control group was treated with mifepristone after operation,and the observation group was treated with mifepristone and Guizhi Fuling capsule after operation.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of transforming growth factor-β1(TGF-β1),epidermal growth factor(EGF)and hypoxia inducible factor-1α(HIF-1α)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the microvessel density and vascular endothelial growth factor(VEGF)level in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).At 6 and 12 months after treatment,the recurrence rate of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Transabdominal myomectomy combined with mifepristone and Guizhi Fuling capsule is effective in the treatment of uterine fibroids.It can effectively inhibit the levels of growth factors,reduce neovascularization and recurrence rate,which is worth promoting.