剖宫产患者术后舌下含服卡前列甲酯栓预防术后出血的效果及对凝血功能的影响

Effect of sublingual Carboprost Methylate Suppositories on postoperative Bleeding Prevention and its Impact on Coagulation Function in cesarean Section Patients

目的分析剖宫产患者术后舌下含服卡前列甲酯栓预防术后出血的效果及对凝血功能的影响。方法采取前瞻性研究,选择2019年4月至2023年4月驻马店市平舆县中心医院收治的130例行剖宫产患者作为研究对象,按随机数字表法分为两组,各65例。对照组给予缩宫素治疗,观察组在对照组基础上给予卡前列甲酯栓治疗。比较两组不同时点(产后1 h、产后2 h、产后24 h)出血量,产后出血发生情况;两组产前、产后血红蛋白水平、凝血功能;记录并比较两组不良反应发生情况。结果观察组发生产后出血率相较对照组低,产后1 h、产后2 h、产后24 h出血量相较对照组低,差异均有统计学意义(P<0.05);产后两组血红蛋白相较产前低,观察组血红蛋白相较对照组高,差异均有统计学意义(P<0.05);产后两组纤维蛋白原(FIB)高于产前,观察组凝血酶时间(TT)、活化部分凝血活酶时间(APTT)时间相较对照组短,FIB水平相较对照组高,差异均有统计学意义(P<0.05);两组不良反应比较差异无统计学意义(P>0.05)。结论剖宫产患者术后舌下含服卡前列甲酯栓能够有效预防术后出血的发生,减少产后出血量,改善机体凝血功能,且不会显著增加不良反应风险。

Objective To analyze the effect of sublingual carboprost methylate suppositories on postoperative bleeding prevention and its impact on coagulation function in cesarean section patients.Methods A prospective study was conducted,130 cesarean section patients admitted to Pingyu County Central Hospital in Zhumadian City from April 2019 to April 2023were selected as the study subjects.They were randomly divided into two groups according to the random number table,with 65 cases in each group.The control group was treated with oxytocin,while the observation group was treated with carboprost methylate suppositories in addition to the control group.The amount of bleeding and the occurrence of postpartum bleeding between two groups at different time points(1 hour postpartum,2 hours postpartum,and 24 hours postpartum)were compared;Two groups of prenatal and postpartum hemoglobin levels and coagulation function were compared;the occurrence of adverse reactions between two groups were recorded and compared.Results The observation group had a lower postoperative bleeding rate compared to the control group,with lower bleeding volume at 1 hour,2 hours,and 24 hours postpartum compared to the control group,and the differences were statistically significant(P<0.05);After childbirth,the hemoglobin levels in the two groups were lower than that before delivery,while the hemoglobin levels in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05);After delivery,the level of fibrinogen(FIB)in both groups were higher than that before delivery.The observation group had shorter thrombin time(TT)and activated partial thromboplastin time(APTT)compared to the control group,and the FIB levels were higher than that in the control group,with statistical significance(P<0.05);There was no statistically significant difference in adverse reactions between the two groups(P>0.05).Conclusion Sublingual carboprost methylate suppositories in cesarean section patients can effectively prevent postoperative bleeding,reduce postpartum bleeding,improve coagulation function,and do not significantly increase the risk of adverse reactions.