胺碘酮联合美托洛尔治疗快速心律失常的临床观察

Clinical Observation of Amiodarone and Metoprolol on the Treatment of Rapid Arrhythmia

目的分析胺碘酮联合美托洛尔在快速心律失常(RA)中的临床疗效。方法选取2021年1月至2022年12月开封市人民医院收治的92例RA患者患者作为研究对象,按照区间随机法引导下均等划分成对照组(46例)与实验组(46例),对照组治疗用药为单纯胺碘酮,实验组治疗用药为胺碘酮联合美托洛尔。围绕两组治疗有效率,治疗前后明尼苏达心功能不全生命质量量表评分(MLFHQ)、心功能指标、内皮功能指标及用药不良反应展开对比研究。结果实验组治疗有效率(97.83%)高于对照组(84.78%),差异有统计学意义(P<0.05)。治疗前组间MLFHQ评分对比,差异无统计学意义(P>0.05);治疗后两组评分均明显降低,且实验组MLFHQ评分低于对照组,差异有统计学意义(P<0.05)。治疗前组间各心功能指标对比,差异无统计学意义(P>0.05);治疗后两组各心功能指标均出现明显恢复,实验组心输出量、左室射血分数、每搏输出量高于对照组,实验组左室收缩末期、舒张末期内径小于对照组,差异有统计学意义(P<0.05)。治疗前组间血管内皮功能指标对比,差异无统计学意义(P>0.05);治疗后实验组内皮素低于对照组,实验组一氧化氮高于对照组,差异有统计学意义(P<0.05);实验组用药期间药物所致的不良反应发生率(6.25%)低于对照组(10.87%),差异无统计学意义(P>0.05)。结论胺碘酮联合美托洛尔是针对RA优质的临床用药方案,疗效、安全性均理想,值得应用。

Objective To analyze the clinical efficacy of Amiodarone and Metoprolol on the treatment of rapid arrhythmia(RA).Methods A total of 92 RA patients treated from January 2021 to December 2022 in Kaifeng People's Hospital were chosen as research samples.According to the guidance of interval random method,they were equally divided into the control group(46 cases)and the experimental group(46 cases).The treatment of the control group was amiodarone alone,and the treatment of the experimental group was amiodarone combined with metoprolol.A comparative study was conducted on the total effective rate of the two groups of treatment,cardiac function indicators,endothelial function indicators,Minnesota Heart Failure Quality of Life Scale Score(MLFHQ),and adverse drug reactions before and after treatment.Results The total effective treatment rates in the test group(97.83%)were significantly higher than control group(84.78%),and the difference was statistically significant(P<0.05);before treatment,MLHFQ scores between groups were not significantly different(P>0.05);after treatment,MLHFQ scores for two groups were reduced,but the descent degrees in the test group were even higher than control group,and the difference was statistically significant(P<0.05);before treatment,the cardiac function indicators between groups were not significantly different(P>0.05);after treatment,the cardiac function indicators for two groups were improved;the cardiac output,left ventricular ejection fraction and stroke volume values in the test group were significantly higher than control group;the left ventricular end-systolic diameter and left ventricular end-diastolic diameter were significantly smaller than control group,and the difference was statistically significant(P<0.05);before treatment,the endothelial function indicators between groups were not significantly different(P>0.05);after treatment,the endothelin contents in the test group were significantly lower than control group;the nitric oxide contents were significantly higher than control group,and the difference was statistically significant(P<0.05);The incidence of adverse reactions caused by drugs in the test group(6.25%)was lower than that in the control group(10.87%),and the difference was not statistically significant(P>0.05).Conclusion Amiodarone combined with metoprolol is a high-quality clinical drug regimen for RA,with ideal efficacy and safety,and is worthy of application.