不同运动方式改善阿尔茨海默病的机制研究

Potential Benefits and Mechanisms of Different Exercise Modalities for Alzheimer's Disease

阿尔茨海默病是一种慢性神经退行性疾病,目前临床尚无特效治疗药物,而运动被认为是一种有效且无害的非医疗干预手段。运动的方式多种多样,不同的运动方式对阿尔茨海默病的改善效果不尽相同。本研究以运动方式的多样性为出发点,综述有氧运动、抗阻运动、高强度间歇运动和多模式运动对阿尔茨海默病的改善作用,分析不同运动方式之间的区别与联系,探究不同运动方式改善阿尔茨海默病的相关机制。虽然不同运动方式改善阿尔茨海默病的机制存在不同,但是均会通过脑源性神经营养因子这一中介缓解疾病进展。本研究可为阿尔茨海默病患者确定最佳运动方式提供理论基础。

Alzheimer's disease is a chronic neurodegenerative disease for which there is currently no effective pharmacological treatment.Exercise is considered to be an effective and harmless non-pharmacological intervention.There are various forms of exercise,which have varying effects on the improvement of Alzheimer's disease.Based on the diversity of exercise modalities,this article reviews the effects of aerobic exercise,resistance exercise,high-intensity interval training,and multimodal exercise on Alzheimer's disease,analyzes the differences and connections between these modalities,and explores the related mechanisms of different exercise modalities in improving Alzheimer's disease.Although the mechanisms by which different exercise modalities improve Alzheimer's disease vary,they all alleviate disease progression through the mediation of brain-derived neurotrophic factors.This article may provide a theoretical basis for determining the best exercise modality for patients with Alzheimer's disease.