5-氟尿嘧啶联合奥沙利铂对结直肠癌患者肿瘤标志物、免疫功能及血清TGF-β1、MMP-7、Smad-7的影响

Effects of 5-fluorouracil Combined with Oxaliplatin on Tumor Markers,Immune Function and Serum TGF-β1,MMP-7 and Smad-7 of Colorectal Cancer Patients

目的:探讨5-氟尿嘧啶联合奥沙利铂治疗结直肠癌患者的临床价值及对肿瘤标志物、免疫功能及血清转化生长因子(TGF)-β1、基质金属蛋白酶(MMP)-7、Smad-7的影响。方法:选取我院2019年5月至2022年5月收治的结直肠癌患者120例,按信封随机法将其分为试验组(n=60)、对照组(n=60)两组。对照组患者施行5-氟尿嘧啶治疗,试验组患者施行5-氟尿嘧啶联合奥沙利铂治疗。比较两组患者给药前、给药6周后的免疫功能、各项肿瘤标志物、血清TGF-β1、MMP-7和Smad-7指标。结果:试验组患者经5-氟尿嘧啶联合奥沙利铂治疗后,有效率为76.67%,高于对照组经5-氟尿嘧啶治疗后的有效率58.33%(P<0.05)。给药6周后,两组患者CD4^(+)指标和CD4^(+)/CD8^(+)比值均升高,CA153、CD8^(+)、CA242和CA19-9指标均降低,且试验组患者CD4^(+)指标和CD4^(+)/CD8^(+)比值升高幅度均大于对照组(P<0.05),CA153、CD8^(+)、CA242和CA19-9指标降低幅度均大于对照组(P<0.05)。给药6周后,两组患者TGF-β1和MMP-7指标均降低,Smad-7指标升高,且试验组患者TGF-β1和MMP-7指标降低幅度均大于对照组(P<0.05),Smad-7指标升高幅度大于对照组(P<0.05)。结论:在结直肠癌患者治疗中,5-氟尿嘧啶联合奥沙利铂的临床疗效显著,有助于改善其免疫功能,降低肿瘤标志物水平,可调节TGF-β1、MMP-7、Smad-7水平。

Objective:To explore the clinical value of 5-fluorouracil combined with oxaliplatin in the treatment of colorectal cancer patients and its effects on tumor markers,immune function and serum transforming growth factor(TGF)-β1,matrix metalloproteinase(MMP)-7 and Smad-7.Methods:A total of 120 patients with colorectal cancer admitted in our hospital from May 2019 to May 2022 were selected and randomly divided into the experimental group(n=60)and the control group(n=60).The patients of the control group were treated with 5-fluorouracil,and the patients of the experimental group were treated with 5-fluorouracil combined with oxaliplatin.The immune function,tumor markers,serum TGF-β1,MMP-7 and Smad-7 levels of the two groups of patients were compared before treatment and after 6 weeks of treatment.Results:The total effective rate of the experimental group after treatment with 5-fluorouracil combined with oxaliplatin was 76.67%,which was higher than the effective rate of the control group after treatment with 5-fluorouracil(58.33%)(P<0.05).After 6 weeks of treatment,the CD4^(+)level and the CD4^(+)/CD8^(+)ratio of patients in both groups increased,while the levels of CA153,CD8^(+),CA242 and CA19-9 decreased in both groups,and the increase range of CD4^(+)level and CD4^(+)/CD8^(+)ratio of patients in the experimental group were higher than those of the control group(P<0.05),the decrease range of CA153,CD8^(+),CA242 and CA19-9 of patients in the experimental group were higher than those of the control group(P<0.05).After 6 weeks of treatment,the TGF-β1 and MMP-7 levels of patients in both groups decreased,while the Smad-7 level of patients in both groups increased,and the decrease range of TGF-β1 and MMP-7 levels of patients in the experimental group were higher than those of the control group(P<0.05),the increase range of Smad-7 level of patients in the experimental group was higher than that of the control group(P<0.05).Conclusion:In the treatment of colorectal cancer,5-fluorouracil combined with oxaliplatin has significant effects,which can help to improve immune function,reduce the level of tumor markers and regulate TGF-β1,MMP-7,Smad-7 level.