头孢曲松钠治疗早期梅毒患者的效果分析

Analyze the therapeutic effect of ceftriaxone sodium on early syphilis patients

目的分析头孢曲松钠治疗早期梅毒患者的效果。方法选取2015年1月至2021年5月大庆龙南医院/齐齐哈尔医学院第五附属医院收治的86例早期梅毒患者作为研究对象,采用随机数字表法分为对照组与观察组,每组43例。对照组采用苄星青霉素治疗,观察组在对照组基础上采用头孢曲松钠治疗。比较两组红细胞相关免疫指标[肿瘤红细胞花环(ATER)、红细胞免疫亲和力受体(FEER)、自然肿瘤红细胞花环率(NTER)、红细胞C3b免疫受体花环(RBC-C3bR)]、外周血T细胞亚群(CD4^(+)、CD3^(+)、CD8^(+)、CD4^(+)/CD8^(+))、血清炎症因子[白细胞介素-10(IL-10)、白细胞介素-18(IL-18)、转化生长因子-β(TNF-β)]水平、快速血浆反应试验转阴率。结果治疗3个月后,两组外周血ATER、FEER、NTER、BC-C3bR水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗3个月后,两组CD4^(+)、CD3^(+)水平及CD4^(+)/CD8^(+)均高于治疗前,CD8^(+)水平低于治疗前,且观察组CD4^(+)、CD3^(+)水平及CD4^(+)/CD8^(+)均高于对照组,CD8^(+)水平低于对照组,差异有统计学意义(P<0.05)。治疗3个月后,两组血清IL-10、IL-18、TNF-β水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗1、2、3个月后,两组快速血浆反应试验转阴率比较差异均无统计学意义。两组不良反应发生率比较差异无统计学意义。结论头孢曲松钠联合苄星青霉素可有效改善早期梅毒患者红细胞相关免疫指标及外周血T细胞亚群、血清炎症因子水平,值得临床推广应用。

Objective To analyze the therapeutic effect of ceftriaxone sodium on early syphilis patients.Methods A total of 86 patients with ear-ly syphilis admitted to Daqing Longnan Hospital/Fifth Affiliated Hospital of Qiqihar Medical College from January 2015 to May 2021 were select-ed as the research subjects,they were divided into the control group and the observation group by random number table method,with 43 cases in each group.The control group was treated with benzathine penicillin,and the observation group was treated with ceftriaxone sodium on the basis of the control group.The red blood cell related immune indexes(tumor erythrocyte rosette[ATER],erythrocyte immune affinity receptor[FEER],natu-ral tumor erythrocyte rosette rate[NTER],erythrocyte C3b immune receptor rosette[RBC-C3 bR]),peripheral blood T cell subsets(CD4^(+),CD3^(+),CD8^(+),CD4^(+)/CD8^(+)),serum inflammatory factors(interleukin-10[IL-10],interleukin-18[IL-18],transforming growth factor-β[TNF-β])levels,and negative conversion rate of rapid plasma reaction test were compared between the two groups.Results After 3 months of treatment,the levels of ATER,FEER,NTER and BC-C3 bR in peripheral blood of the two groups were higher than those before treatment,and the observation group was higher than the control group,the differences were statistically significant(P<0.05).After 3 months of treatment,the levels of CD4^(+),CD3^(+)and CD4^(+)/CD8^(+)of the two groups were higher than those before treatment,and the level of CD8^(+)was lower than that before treatment,and the levels of CD4^(+),CD3^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,and the level of CD8^(+)was lower than that in the control group,the differences were statistically significant(P<0.05).After 3 months of treatment,the levels of serum IL-10,IL-18 and TNF-βof the two groups were lower than those before treatment,and the observation group was lower than the control group,the differences were statistically sig-nificant(P<0.05).After 1,2 and 3 months of treatment,there were no significant differences in the negative conversion rate of rapid plasma reaction test between the two groups.There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Ceftriax-one sodium combined with benzathine penicillin can effectively improve the erythrocyte-related immune indexes,the level of T cell subsets in periph-eral blood and the level of serum inflammatory factors in patients with early syphilis,which is worthy of clinical promotion and application.