普瑞巴林治疗带状疱疹后遗三叉神经痛的临床疗效及对患者生命质量的影响

The clinical efficacy of pregabalin in the treatment of postherpetic trigeminal neuralgia and its impact on the quality of life of patients

目的探究普瑞巴林治疗带状疱疹后遗三叉神经痛的临床疗效及对患者生命质量的影响。方法选取2018年8月至2020年9月株洲市人民医院收治的94例带状疱疹后遗三叉神经痛患者作为研究对象,按照随机数字表法分为两组,各47例。两组均行星状神经节阻滞联合维生素B1片、甲钴胺片治疗,在此基础上,对照组联合卡马西平片治疗,观察组联合普瑞巴林治疗。比较两组临床疗效及治疗前后睡眠质量[匹兹堡睡眠质量指数量表(PSQI)]、疼痛程度[视觉模拟评分法(VAS)]、生命质量[生命质量综合评定问卷(GQOL-74)]评分及不良反应。结果观察组治疗总有效率为95.74%,高于对照组的76.60%,差异有统计学意义(P<0.05);治疗后,两组PSQI、VAS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组物质生活、心理功能、社会功能、躯体功能评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为12.77%,高于对照组的10.64%,但差异无统计学意义。结论普瑞巴林治疗带状疱疹后遗三叉神经痛效果显著,可减轻患者疼痛度,提高患者生命质量,值得临床推广应用。

Objective To explore the clinical efficacy of pregabalin in the treatment of postherpetic trigeminal neuralgia and its impact on the quality of life of patients.Methods 94 patients with postherpetic trigeminal neuralgia admitted to Zhuzhou People's Hospital from August 2018 to September 2020 were selected as the study subjects.They were randomly divided into two groups according to the random number table method,with 47 cases in each group.Both groups were treated with planetary ganglion block combined with vitamin B1 and methylcobalamin tablets,on this basis,the control group was treated with carbamazepine tablets,while the observation group was treated with pregabalin.The clinical efficacy and sleep quality(Pittsburgh sleep quality index[PSQI]),pain degree(visual analog scale[VAS]),quality of life score(comprehensive quality of life as-sessment questionnaire-74[GQOL-74])before and after treatment,and adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 95.74%,which was higher than 76.60%in the control group,and the difference was statistically significant(P<0.05);after treatment,the PSQI and VAS scores of the two groups were lower than before treatment,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05);after treatment,the scores of material life,psychological function,social function,and physical function of the two groups were higher than before treatment,and the observation group was higher than the control group,and the differences were statistically significant(P<0.05);the incidence of adverse reactions in the observation group was 12.76%,which was higher than 10.64%in the control group,but the difference was not statistically significant.Conclusion Pregabalin has significant therapeutic effect on postherpetic trigeminal neuralgia,which can reduce patient pain and improve their quality of life,it is worthy of clinical promotion and application.