督脉悬灸结合针刺对寒湿痹阻型强直性脊柱炎患者炎症因子、病情活动指数及预后的影响

Effects of suspended moxibustion of governor meridian combined with acupuncture on inflammatory factor,disease activity index and prognosis in patients with ankylosing spondylitis of cold-dampness obstruction type

目的观察督脉悬灸结合针刺对寒湿痹阻型强直性脊柱炎(AS)患者炎症因子、病情活动指数及预后的影响。方法将60例寒湿痹阻型AS患者按照随机数字表法分为2组,对照组30例予常规西药治疗,治疗组30例予督脉悬灸结合针刺治疗。比较2组疗效;比较2组治疗前后中医证候积分变化;比较2组治疗前后炎症因子水平变化;比较2组治疗前后AS功能指数(BASFI)评分、AS疾病活动指数(BASDAI)评分及焦虑自评量表(SAS)、抑郁自评量表(SDS)评分变化;比较2组治疗前后简明健康调查问卷量表(SF-36)评分变化;比较2组复发情况。结果治疗组总有效率93.34%(28/30),对照组总有效率70.00%(21/30),治疗组疗效优于对照组(P<0.05)。2组治疗4、6、8周后中医证候积分均较本组治疗前降低(P<0.05),且治疗组治疗后中医证候积分低于对照组同期(P<0.05)。2组治疗后C反应蛋白(CRP)、红细胞沉降率(ESR)水平均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。2组治疗后BASFI评分、BASDAI评分及SAS、SDS评分均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。2组治疗后SF-36评分均较本组治疗前升高(P<0.05);治疗后治疗组SF-36评分均高于对照组(P<0.05)。治疗组复发率低于对照组(P<0.05)。结论督脉悬灸结合针刺可降低AS患者炎症水平,改善病情,预后良好。

Objective To observe the effects of suspended moxibustion of governor meridian combined with acupuncture on inflammatory factor,disease activity index and prognosis in patients with ankylosing spondylitis(AS)of cold-dampness obstruction type.Methods Sixty AS patients(cold-dampness obstruction type)were randomly assigned to the control group(n=30)and the treatment group(n=30),in which they were treated with conventional Western medicine and suspended moxibustion of governor meridian combined with acupuncture,respectively.The aim was to compare traditional Chinese medicine(TCM)syndrome score,Bath AS Functional Index(BASFI),Bath AS Disease Activity Index(BASDAI),self-rating anxiety scale(SAS),self-rating depression scale(SDS),Short Form 36 Health Survey Questionnaire(SF-36).The curative effect and recurrence were assessed.Results The overall effective rate in the treatment group was better than that in the control group(93.34%[28/30]vs 70.00%[21/30],[P<0.05],respectively).TCM symptom scores on weeks 4,6 and 8 in the both groups were significantly decreased(P<0.05),which decreased notably in the treatment group compared with the concurrent control group(P<0.05).After treatment,C-reactive protein(CRP),erythrocyte sedimentation rate(ESR)in the both groups were significantly decreased(P<0.05),which were significantly lower in the treatment group than in the control group(P<0.05).The scores of BASFI,BASDAI,SAS,SDS in the both groups were significantly decreased(P<0.05),the treatment group was more prevalent(P<0.05).Significantly higher quality of life,and lower recurrence rate were detected in the treatment group than those of the control group(all P<0.05).Conclusion For AS patients,suspended moxibustion of governor meridian combined with acupuncture can reduce inflammation levels,improve condition,and with good prognosis.