载药微球经导管动脉化疗栓塞治疗原发性肝癌患者的临床疗效及安全性

Clinical efficacy and safety of drug-loaded microspheres for transcatheter arterial chemoembolization in the treatment of primary liver cancer

目的探讨载药微球经导管动脉化疗栓塞治疗原发性肝癌患者的临床疗效及安全性。方法根据治疗方式的不同将88例原发性肝癌患者分为对照组(n=41)和观察组(n=47),对照组患者予以空白微球结合碘油经导管动脉化疗栓塞治疗,观察组患者予以载药微球经导管动脉化疗栓塞治疗。比较两组患者的临床疗效、并发症发生情况及2年生存情况。采用多因素Logistic回归模型分析原发性肝癌患者预后的影响因素。结果观察组患者的总有效率为85.11%,高于对照组患者的60.98%,差异有统计学意义(P﹤0.05)。观察组患者的并发症总发生率为8.51%,低于对照组患者的24.39%,差异有统计学意义(P﹤0.05)。观察组患者的2年生存率为76.60%,高于对照组患者的56.10%,差异有统计学意义(P﹤0.05)。多因素Logistic回归分析结果显示,血清天冬氨酸转氨酶(AST)水平、血清总胆红素(TBIL)水平、美国东部肿瘤协作组(ECOG)体力状况(PS)评分、卡氏功能状态(KPS)评分、治疗方式均是原发性肝癌患者预后的独立影响因素(P﹤0.05)。结论载药微球经导管动脉化疗栓塞治疗原发性肝癌患者可提高临床疗效,且安全性较高。

Objective To investigate the clinical efficacy and safety of drug-loaded microspheres for transcatheter arterial chemoembolization in the treatment of primary liver cancer.Method A total of 88 patients with primary liver cancer were selected and divided into the control group(n=41,treated with blank microspheres combined with lipiodol transcatheter arterial chemoembolization)and observation group(n=47,treated with drug-loaded microspheres transcatheter arterial chemoembolization)according to different treatment methods.The clinical efficacy,complications and 2-year survival of the two groups were compared.Multivariate Logistic regression model was used to analyze the influencing factors affecting the prognosis of patients.Result The total effective rate of the observation group was 85.11%,higher than 60.98%of the control group(P<0.05).The total incidence of complications in the observation group was 8.51%,lower than 24.39%in the control group(P<0.05).The 2-year survival rate of the observation group was 76.60%,higher than 56.10%of the control group(P<0.05).Multivariate Logistic regression analysis showed that serum aspartate aminotransferase(AST)level,serum total bilirubin(TBIL)level,Eastern Cooperative Oncology Group(ECOG)performance status(PS)score,Karnofsky performance status(KPS)score and treatment method were independent influencing factors for prognosis of primary liver cancer patients(P<0.05).Conclusion Drug-loaded microspheres transcatheter arterial chemoembolization in the treatment of patients with primary liver cancer can improve clinical efficacy with higher safety.