术前血清NLR、PLR以及超声特征在良恶性甲状腺结节中的鉴别诊断价值分析

Analysis of diagnostic value of preoperative serum NLR,PLR and ultrasonic feature in differential diagnosis of benign and malignant thyroid nodules

目的探究术前血清中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)以及超声特征在良恶性甲状腺结节中的鉴别诊断价值。方法70例甲状腺结节患者作为研究对象,根据术后病理结果分为恶性组、良性组,每组35例。术前两组患者均开展超声检查、实验室检查。对比两组不同结节大小患者NLR,两组患者PLR,恶性组不同肿瘤分期、被膜侵犯、中央区发生淋巴转移情况患者NLR。结果良性组结节大小≤1.0 cm患者NLR(1.43±0.61)低于恶性组结节大小≤1.0 cm患者的(2.06±0.91),差异具有统计学意义(P<0.05);良性组结节大小>1.0 cm患者NLR(1.46±0.72)低于恶性组结节大小>1.0 cm患者的(1.97±0.61),差异具有统计学意义(P<0.05)。良性组患者PLR(1.62±0.61)低于恶性组的(1.91±0.12),差异有统计学意义(P<0.05)。恶性组不同肿瘤分期、有无侵犯被膜、有无中央区淋巴结转移患者NLR对比差异无统计学意义(P>0.05)。结论术前血清NLR、PLR在良恶性甲状腺结节中具有显著的鉴别诊断价值,恶性结节的肿瘤分期、被摸侵犯及中央区发生淋巴结转移与NLR无关。

Objective To investigate the diagnostic value of preoperative serum neutrophil-tolymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR)and ultrasonic feature in differential diagnosis of benign and malignant thyroid nodules.Methods 70 patients with thyroid nodules were studied and divided into malignant group and benign group according to postoperative pathological results,with 35 cases in each group.Preoperative ultrasonography and laboratory examination were performed in both groups.Comparison was made on NLR of patients with different nodule sizes in the two groups,PLR of patients in the two groups,and NLR of patients with different tumor stages,capsule invasion and central lymph node metastasis in the malignant group.Results NLR of(1.43±0.61)of patients with nodule size≤1.0 cm in benign group was lower than that of(2.06±0.91)of patients with nodule size≤1.0 cm in malignant group,and the difference was statistically significant(P<0.05).NLR of(1.46±0.72)of patients with nodule size>1.0 cm in benign group was lower than that of(1.97±0.61)of patients with nodule size>1.0 cm in malignant group,and the difference was statistically significant(P<0.05).PLR of(1.62±0.61)in benign group was lower than that of(1.91±0.12)in malignant group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in NLR among patients with different tumor stages,patients with or without capsule invasion,patients with or without central lymph node metastasis in the malignant group(P>0.05).Conclusion Preoperative serum NLR and PLR have significant diagnostic value in the differential diagnosis of benign and malignant thyroid nodules,and the tumor stage,capsule invasion and central lymph node metastasis of malignant nodules are not related to NLR.