基于非牛顿血液模型预测主动脉夹层的形成

Predicting the formation of aortic dissection using a non-Newtonian model

采取体外模拟主动脉血管血流情况的手段,通过使用非牛顿流体血液模型来优化血液模型,并基于双向流-固耦合进行数值模拟分析,分析一个心脏跳动周期内主动脉模型中的血流速度、血管壁面压力和血管壁面应力的分布情况,讨论其与主动脉夹层形成的关系,实践有限元软件在力学中的应用,得出血管内长期存在“杂乱”的血流分布、壁面压力和壁面应力的突变十分容易引起动脉血管壁细胞结构和功能发生改变,最终诱发主动脉夹层的形成,这为医生进行医疗诊断提供较为可靠的依据,进一步实现对患者生命健康安全的保护。

The blood flow in the aortic arch and branch vessels in vitro is simulated,and the blood model is optimized with a non-Newtonian model.A numerical simulation analysis is conducted based on bidirectional fluid-solid coupling to analyze the hemodynamic characteristics(blood flow velocity,vascular wall pressure and vascular wall stress)in a cardiac cycle,and discuss their relationships with the formation of aortic dissection.It is concluded that the long-term existence of"chaotic"blood flow distribution in the blood vessel and the sudden changes of wall pressure and wall stress are liable to cause changes in the structure and function of the cells of the arterial wall,and ultimately induce the formation of aortic dissection.The study provides a more reliable basis for medical diagnosis,and further protects the life,health and safety of patients.