专利中药复方治疗脑出血的用药规律

Medication laws of patented Chinese medicine compound prescription in treating intracerebral hemorrhage

目的 探究专利中药复方治疗脑出血的用药规律,为临床新方开发提供参考。方法 检索国家知识产权局中国专利公布网中建库至2022年10月治疗脑出血的专利中药复方数据;使用Microsoft Office Excel 2019和IBM SPSS Statistics 20.0软件进行药物、功效类别频次统计和系统聚类分析;应用中医传承辅助平台v2.5进行药性、药味、归经频次统计;利用IBM SPSS Modeler 18.0软件中Apriori关联规则进行建模分析;运用Cytoscape 3.9软件构建中药共现核心复杂网络,提取出联系紧密的中药组群。结果 共纳入中药复方85个,涉及药物332味,高频中药有红花、当归、黄芪等;中药类别主要是活血化瘀药、平肝息风药和补虚药;中药性味以温、苦为主,归经多归于肝经;常用药对有天麻-钩藤、川芎-桃仁等;常用药组有红花-当归-黄芪、当归-桃仁-红花等;通过系统聚类分析获得4个新的中药组群。结论 专利中药复方治疗脑出血的主要治法为活血化瘀、平肝息风和补益气血,可作为进一步组方用药的参考。

Objective To explore the rule of using patented Chinese medicine compound prescription in treating cerebral hemorrhage,and to provide reference for developing new clinical prescription.Methods The data of the patented traditional Chinese medicine compound for the treatment of cerebral hemorrhage were retrieved from the database of China Patent Publication Network of the State Intellectual Property Office from October 2022.Microsoft Office Excel 2019 and IBM SPSS Statistics 20.0 software were used for drug and efficacy category frequency statistics and systematic cluster analysis.The tra-ditional Chinese medicine inheritance platform v2.5 was used to carry out the statistics of medicinal properties,medicinal tastes and menstrual conversion frequency.The Apriori association rule in IBM SPSS Modeler 18.0 software was used for modeling analysis.The complex core network of traditional Chinese medicine co-occurrence was constructed by Cytoscape 3.9 software,and the closely related traditional Chinese Medicine groups were extracted.Results A total of 85 traditional Chinese medicine compound prescription were included,involving 332 flavors.The high frequency traditional Chinese medicine included Floslarthami,Radix Angelicae Sinensis,Radix Astragaliseu Hedysari,etc.The main categories of Chinese medicine were activating blood circulation and removing blood stasis,calming liver,and calming wind,and tonifying deficiency.The taste of Chinese medicine was mainly warm and bitter,which belonged to liver channel.The commonly used pairs weree Rhizomu Gastrodiae-Ramulus Uncariae Cum Uncis,Rhizoma Ligustici Chuan Xiong-Semen Persicae,etc.Common drug groups included Floslarthami-Radix Angelicae Sinensis-Radix Astragaliseu Hedysari,Radix Angelicae Sinensis-Semen Persicae-Floslarthami,etc.;four new traditional Chinese medicine groups were obtained by systematic cluster analysis.Conclusion The main therapeutic methods of the patented Chinese medicine compound in the treatment of cerebral hemorrhage are promoting blood circulation and removing blood stasis,calming liver and calming wind,and tonifying qi and blood,which can be used as reference for further prescription medicine.