基于数据挖掘分析刘艳巧教授治疗多囊卵巢综合征的用药规律

Analysis of Professor Liu Yanqiao’s medication rules in the treatment of polycystic ovary syndrome based on data mining

目的基于数据挖掘分析刘艳巧教授治疗多囊卵巢综合征(PCOS)的处方用药规律。方法筛选西安交通大学第二附属医院刘艳巧教授2019年10月至2023年2月治疗的PCOS病案,录入Excel建立数据库,统计处方的药物频次、功效归类、性味归经等;采用R语言及SPSS Statistics软件进行关联规则及聚类分析。结果共收集处方131首,中药115味,使用频次>40次的药物共20味,频次最高的是山药、香附均90次,多属于补虚药和活血化瘀药,药味多甘、苦,药性以温性、寒性药物为主,归肝(胆)经最多。关联规则分析显示,常用药对有13种,当归-川芎支持度最高;3味药组合有13种,香附-当归-川芎支持度最高。基于聚类分析,获得3组聚类方,分别对应肾虚血瘀型,痰瘀阻滞型及脾虚痰湿型。结论刘艳巧教授治疗PCOS时,在补肾健脾疏肝的基础上,配合活血化瘀、祛湿化痰等法,以顺应卵泡生长发育和排出的生理过程。

Objective To analyze Professor Liu Yanqiao’s prescription medication rules in the treatment of polycystic ovary syndrome(PCOS)based on data mining analysis.Methods The PCOS medical cases treated by Professor Liu Yanqiao from the Second Affiliated Hospital of Xi’an Jiaotong University from October 2019 to February 2023 were screened,and input into Excel to establish a database,prescription drug frequency,efficacy classification,flavor and meridian tropism were counted;R language and SPSS Statistics software were used for association rules and cluster analysis.Results A total of 131 prescriptions were collected,including 115 flavors of traditional Chinese medicine,and 20 flavors were used more than 40 times,the highest frequency was Shanyao and Xiangfu 90 times,most of which belonged to tonifying deficiency drugs and promoting blood circulation and removing blood stasis drugs,with sweet and bitter tastes,mainly warm and cold drugs,and most of them were attributed to liver(gallbladder)channel.Association rule analysis showed that there were 13 common drug pairs,and the support of angelica-Chuanxiong was the highest,and there were 13 kinds of three kinds of medicine combination,and the support of Xiangfu-angelica-Chuanxiong was the highest.Based on cluster analysis,three groups of cluster prescriptions were obtained,corresponding to kidney deficiency and blood stasis type,phlegm stasis block type,and spleen deficiency and phlegm dampness type respectively.Conclusion In the treatment of PCOS,Professor Liu Yanqiao combines with promoting blood circulation and resolving stasis,dispelling dampness and resolving phlegm,etc.on the basis of tonifying the kidney,strengthening the spleen,and soothing the liver,in order to comply with the physiological process of follicle growth,development,and excretion.