2型糖尿病发生动脉硬化的影响因素分析

Analysis of influencing factors of atherosclerosis in type 2 diabetes mellitus

目的 探讨2型糖尿病(T2DM)患者发生动脉硬化(AS)的影响因素。方法 选取2019年7月至2021年9月于南京鼓楼医院集团宿迁医院内分泌科住院的T2DM患者120例,根据彩超结果分为AS组(60例)和非AS组(60例)。比较两组一般临床资料;logistic回归分析AS危险因素;受试者操作特征(ROC)曲线分析内脏脂肪面积(VFA)预测AS风险能力。结果 两组年龄、收缩压、体重指数、VFA、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、空腹血糖、稳态模型胰岛素抵抗指数、糖尿病微血管病变及高血压比较,差异有统计学意义(P<0.05)。logistic回归分析显示VFA、年龄、甘油三酯是T2DM患者发生AS的独立危险因素(P<0.05);ROC曲线显示,VFA预测T2DM患者AS的曲线下面积为0.702,临界值为114.7 cm2,灵敏度为0.617,特异度为0.733。结论 VFA增多尤其是VFA>114.7 cm2与T2DM患者发生AS密切相关。

Objective To explore the influencing factors of arteriosclerosis(AS)in type 2 diabetes mellitus(T2DM)patients.Methods A total of 120 patients with T2DM who were hospitalized in Department of Endocrinology,Nanjing Drum Tower Hospital Group Suqian Hospital from July 2019 to September 2021 were selected,and divided into arteriosclerosis group(60 cases)and non-atherosclerosis group(60 cases)according to the color doppler ultrasound results.The general clinical data of the two groups were compared;and the risk factors of AS were analyzed by logistic regression;receiver operating characteristic(ROC)curve was used to analyse the ability of visceral fat area(VFA)to predict AS risk.Results There were significant differences in age,systolic blood pressure,body mass index,VFA,total cholesterol,triglyceride,low density lipoprotein cholesterol,fasting blood glucose,steady-state model insulin resistance index,diabetic microanglopathy,and hypertension between the two groups(P<0.05).Logistic regression analysis showed that VFA,age and triglyceride were independent risk factors for AS in T2DM patients(P<0.05).ROC curve showed that the area under the curve of VFA in predicting AS in T2DM patients was 0.702,the critical value was 114.7 cm2,the sensitivity was 0.617,and the specificity was 0.733.Conclusion Increased VFA,especially VFA>114.7 cm2 is closely related to the occurrence of AS in T2DM patients.