内质网钙离子结合蛋白1对肝细胞癌患者预后的预测价值及阈值效应分析

Prognostic value and threshold effect analysis of reticulocalbin-1 in patients with hepatocellular carcinoma

目的探讨内质网钙离子结合蛋白1(reticulocalbin-1,RCN1)对肝细胞癌(hepatocellular carcinoma,HCC)患者预后的预测价值。方法回顾性收集2020年1月至2021年6月河南科技大学第一附属医院收治的399例HCC患者作为研究对象,术后随访1年,根据预后情况将其分为预后良好组(n=310)和预后不良组(n=89)。收集入选患者的临床资料及实验室指标,采用多因素Logistic回归分析影响HCC患者预后的危险因素。采用平滑拟合曲线并进行阈值效应分析RCN1对HCC患者预后情况。结果RCN1≤42.36μg/g时,随着RCN1水平增加,患者预后不良率不受影响(OR=1.001,95%CI:0.815~1.958,P<0.001),RCN1>42.36μg/g时,随着RCN1水平增加,患者预后不良率明显增加(OR=1.239,95%CI:1.006~1.782,P<0.001)。列线图模型预测的准确性较高,临床适用性较好。结论RCN1对HCC患者预后情况有一定的预测价值,临床研究应加以重视。

Objective To investigate the predictive value of reticulocalbin-1(RCN1)and its prognosis in hepatocellular carcinoma(HCC)patients.Methods Retrospectively collected 399 HCC patients admitted to The First Affiliated Hospital of Henan University of Science and Technology from Jan.2020 to Jun.2021 as study subjects.They were followed up for 1 year after surgery and divided into good prognosis group(n=310)and poor prognosis group(n=89).Clinical data and laboratory indicators of the selected patients were collected,and a multivariate Logistic regression was used to analyze the risk factors affecting the prognosis of HCC patients.The prognosis of the RCN1 in HCC patients was analyzed by fitting the curve smoothly and performing the threshold effects.Results At RCN1≤42.36μg/g,with RCN1 levels increased,the poor prognosis rate of patients was not affected(OR=1.001,95%CI:0.815-1.958,P<0.001).While at RCN1>42.36μg/g,with RCN1 levels increased,the incidence of poor prognosis in patients significantly increased(OR=1.239,95%CI:1.006-1.782,P<0.001).The nomogram model was predicted with high accuracy and good clinical applicability.Conclusion RCN1 has some predictive value for the prognosis of HCC patients,clinical research showld be given attention.