摘要
目的探讨肿瘤标志物联合超声内镜引导下细针穿刺(endoscopic ultrasonography-guided fine needle aspiration,EUS-FNA)对胰腺占位的诊断价值,并分析其相关影响因素。方法选取2021年8月至2022年8月于重庆医科大学附属第一医院确诊的68例胰腺占位患者,全部患者均完成EUS-FNA,分析患者的临床资料及病理结果。结果68例患者中,EUS-FNA对胰腺占位诊断的准确率为94.12%、灵敏度为92.86%、特异度为100%;EUS-FNA穿刺阳性患者年龄>60岁、胰腺占位大小>2 cm、穿刺次数≥3次的比例高于穿刺阴性患者;恶性胰腺占位组CA19-9水平高于良性胰腺占位组;CA19-9对恶性胰腺占位诊断的准确率为75.00%、灵敏度为75.00%、特异度为75.00%;CA19-9联合EUS-FNA对恶性胰腺占位诊断的准确率为97.06%、灵敏度为96.43%、特异度为100%。结论EUS-FNA诊断胰腺占位安全且准确率较高;EUS-FNA诊断胰腺占位的影响因素有穿刺次数、占位大小、年龄;EUS-FNA联合肿瘤标志物CA19-9可提高诊断胰腺占位的准确性。
Objective To investigate the value of tumor markers combined with endoscopic ultrasonography-guided fine needle aspiration(EUS-FNA)for pancreatic mass and its related influencing factors.Methods A total of 68 patients with pancreatic mass in the First Affiliated Hospital of Chongqing Medical University from Aug.2021 to Aug.2022 were selected.All patients were treated with EUS-FNA,and the clinical data and pathological results of the patients were analyzed.Results The accuracy,sensitivity and specificity of EUS-FNA in the diagnosis of pancreatic mass were 94.12%,92.86%and 100%,respectively.The proportion of EUS-FNA puncture positive patients with age>60 years old,occupation size>2 cm,puncture times≥3 times were higher than that of puncture negative patients.The level of CA19-9 in malignant pancreatic mass group was higher than that in benign pancreatic mass group.The accuracy,sensitivity and specificity of CA19-9 in the diagnosis of malignant pancreatic lesions were 75.00%,75.00%and 75.00%,respectively.The accuracy,sensitivity and specificity of CA19-9 combined with EUS-FNA in the diagnosis of malignant pancreatic lesions were 97.06%,96.43%and 100%,respectively.Conclusion EUS-FNA is safe and accurate in the diagnosis of pancreatic mass.The influencing factors of EUS-FNA in diagnosis of pancreatic mass included puncture times,occupation size and age.EUS-FNA combined with tumor marker CA19-9 can improve the accuracy of diagnosis of pancreatic mass.
作者
郭蒙
谯敏
GUO Meng;QIAO Min(Department of Gastroenterology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)
出处
《胃肠病学和肝病学杂志》
CAS
2023年第12期1385-1388,共4页
Chinese Journal of Gastroenterology and Hepatology