正清风痛宁联合厄贝沙坦对特发性膜性肾病Ⅱ期蛋白尿的影响

Effect of Zhengqing Fengtongning Combined with Irbesartan on StageⅡProteinuria in Idiopathic Membranous Nephropathy

目的:分析正清风痛宁联合厄贝沙坦治疗特发性膜性肾病Ⅱ期患者的临床优势。方法:纳入2021年10月—2022年11月于九江市中医医院治疗的40例特发性膜性肾病Ⅱ期患者,随机分为观察组和对照组,各20例,观察组选用正清风痛宁缓释片联合厄贝沙坦片治疗,对照组仅给予厄贝沙坦片治疗。观察比较2组的血脂水平、血白蛋白、24 h尿蛋白定量及临床治疗效果。结果:观察组在实验室指标比较中降脂效果优于对照组,差异具有统计学意义(P<0.05);观察组患者总有效率为95.00%,高于对照组的75.00%,差异具有统计学意义(P<0.05);在血白蛋白和24 h尿蛋白定量比较中观察组优于对照组,差异具有统计学意义(P<0.05)。结论:采用正清风痛宁联合厄贝沙坦治疗特发性膜性肾病Ⅱ期患者,有助于降低患者血脂水平、24 h尿蛋白,提升血清白蛋白等实验室指标,值得推广。

Objective:For the treatment of patients with stageⅡidiopathic membranous nephropathy,the clinical advantages of Zhengqing Fengtongning combined with irbesartan were analyzed to improve the treatment efficacy.Methods:Forty patients with stageⅡidiopathic membranous nephropathy were included as the study subjects from October 2021 to November 2022,and were randomly divided into observation group and control group,20 cases in each group,and the observation group selected Zhengqing Fengtongning and tranquility sustained-release tablets and irbesartan tablets.The control group was treated with irbesartan tablets.Observe the comparison Lipid�lowering levels,blood albumin,24-hour urine protein quantification and clinical treatment effect.Results:From the data,it can be seen that the observation group decreased in the comparison of laboratory indicators.The lipid effect was better than that of the control group.There was a statistically significant(P<0.05),and 95.00%of the patients in the total efficacy group were higher than 75.00%in the control group,with a significant difference(P<0.05).By the comparison of albumin and 24-hour urine protein quantification,the observation group was better than the control group,and the comparison difference was significant(P<0.05).Conclusion:The use of Zhengqing Fengtongning combined with irbesartan in the treatment of patients with idiopathic membranous nephropathy can help reduce blood lipid levels,increase serum albumin,and reduce 24-hour urine protein quantification laboratory indicators such as urine protein improve the efficacy of treatment,so it is worth promoting.