PG1/PG2与肿瘤标志物预测中晚期胃癌近期生存

Prediction of PG1/PG2 and tumor markers on short-term survival in advanced gastric cancer

目的:分析血清PG1/PG2、CEA、CA125预测中晚期胃癌近期生存的价值。方法:选取110例中晚期胃癌患者和110例健康志愿者。检测血清PG1、PG2、CEA、CA125,随访1年。结果:癌症组血清PG1/PG2更低(P<0.05),CEA、CA125更高(P<0.05),且均与胃癌分期、病理类型、近期生存有关(P<0.05);血清PG1/PG2、CEA、CA125联合预测的AUC更高(P<0.05)。结论:中晚期胃癌血清PG1/PG2下降,CEA、CA125升高,与临床病理特征有关,且联合预测近期生存的价值高。

Objective:To analyze the value of analyzing serum PG1/PG2,CEA,and CA125 in predicting short-term survival of advanced gastric cancer.Methods:110 patients with advanced gastric cancer and 110 healthy volunteers were selected.Serum PG1,PG2,CEA,CA125 were detected,and the patients were followed up for 1 year.Results:Serum PG1/PG2 in the cancer group was lower(P<0.05),while CEA and CA125 levels were higher(P<0.05),all of which were related to gastric cancer stage,pathological types and recent survival(P<0.05).The combined prediction of serum PG1/PG2,CEA and CA125 had a higher AUC(P<0.05).Conclusion:The decrease of serum PG1/PG2 and the increase of CEA and CA125 in advanced gastric cancer are related to clinical pathological characteristics,and the combined prediction of short-term survival has high value.