络合法提取胆固醇的研究进展

Progress on the separation of cholesterol with complexation method

络合法提取胆固醇的影响因素包括络合剂种类、溶剂组成、溶剂总量、络合温度、络合时间和解络条件等。常用的络合剂为氯化钙等无机盐类,但有机酸和皂苷也有作为络合剂的潜力;非质子性溶剂用量一般显著多于质子性溶剂;络合温度升高有利于提高收率。建议深入研究络合过程机理,明确络合物在不同溶剂体系中的溶解度规律,加强络合过程建模方法研究。

The composition of solvents,the ratio of solvents,the type and amounts of complex compounds,the conditions of decomplexation and the temperature all have effects on the complexation process.The commonly used complex compounds are inorganic salts such as calcium chloride,and besides.Organic acids and saponins also have the potential to act as complex compound.Aprotic solvent is generally used significantly more than protic solvent.Increasing the temperature is beneficial to improve the yield.It is suggested to study the mechanism of complexation process,clarify the rule of the solubility of complex in different solvent systems,strengthen the modeling method of complexation process.