细胞外囊泡介导的胶质细胞交互作用对神经炎症的调节意义及研究进展

Regulatory significance and research progress of extracellular vesicle-mediated glial interactions on neuroinflammation

神经炎症既可作为癫痫、阿尔茨海默病和脑损伤等的致病因素,也可作为其继发反应,是中枢神经系统(CNS)疾病发生发展的重要机理。胶质细胞在神经炎症调节中充当重要角色,小胶质细胞-星形胶质细胞的交互作用对CNS炎症也具有关键调节意义。此外,细胞外囊泡(EVs)对CNS损伤具有炎症调节和神经保护功能。因此,本文综述了星形胶质细胞和小胶质细胞以及它们之间的交互作用对神经系统的调节功能,阐明内源性EVs对CNS炎性疾病的调节意义,以此为基础探究外源性EVs对星形胶质细胞和小胶质细胞间交互作用的调节机制,以便进一步研究CNS疾病的发病转归及治疗。

Neuroinflammation serves as both a causative factor and secondary response in central nervous system(CNS)diseases such as epilepsy,Alzheimer's disease,and brain injury,as well as is an important mechanism of the disease initiation and progression.Notably,glial cells play an important role in regulating neuroinflammation,and the interactions between microglia and astrocytes have a key regulatory significance in CNS inflammation.Additionally,extracellular vesicles(EVs)have inflammatory modulation and neuroprotective functions in CNS injuries.Therefore,this review summarized the regulatory functions of astrocytes,microglia,and their interactions in the CNS,elucidated the regulatory significance of endogenous EVs in neuroinflammatory diseases,and explored the regulatory mechanisms of exogenous EVs on the interaction between astrocytes and microglia,aiming further to investigate the pathogenesis and treatment of CNS diseases.