实体肿瘤外周血细胞免疫功能实验室检测专家共识

Chinese expert consensus on laboratory detection of peripheral blood cellular immune function in solid tumors

外周血细胞免疫功能检测在实体肿瘤免疫治疗受益者筛选、免疫相关不良反应监测、肿瘤疗效及预后评估等方面受到临床关注。为促进临床有效选择和解读实体肿瘤诊疗相关的外周血细胞免疫功能指标,中国医师协会检验医师分会、北京医师协会医学检验专科医师(技师)分会、国家癌症中心、国家肿瘤区域医疗中心、国家医学检验临床医学研究中心(中国医科大学附属第一医院)组织相关领域的学术专家,对外周血细胞免疫功能指标包括T淋巴细胞亚群精细分型、髓源性抑制细胞和细胞因子的临床应用价值进行了充分总结,并撰写了专家共识,同时对外周细胞免疫功能实验室检测指标和方案或方法给出了推荐和参考方向,以期为实体肿瘤患者的精准诊疗提供帮助。

The value of peripheral blood cellular immune function detection has received clinical attention in screening beneficiaries of solid tumor immunotherapy,monitoring immune-related adverse events(irAE),and evaluating tumor efficacy and prognosis.In order to assist in the effective selection and interpretation of peripheral blood cellular immune function indicators to further optimize the diagnosis and treatment of solid tumors,the Laboratory Medicine Society of Chinese Medical Association,the Laboratory Medicine Specialist(Technician)Branch of Beijing Medical Doctor Association,the National Cancer Center/National Cancer Regional Medical Center and the National Clinical Research Center of Laboratory Medicine(The First Hospital of China Medical University)organized several well-known experts in relevant fields.The clinical application value of peripheral blood cellular immune function,including deep phenotyping of T-lymphocyte subpopulations,myeloid-derived suppressor cells(MDSC)and cytokines,were fully discussed,and the expert consensus was written.Meanwhile,recommendations and reference directions have been given for laboratory detection indicators and protocols or methods of peripheral blood cellular immune function,aiming to provide help for precise diagnosis and treatment of solid tumor patients.