乳腺癌术后内分泌药物对肿瘤标志物及子宫内膜的影响

Effect of endocrine drugs on tumor markers and endometrium after breast cancer surgery

目的探讨乳腺癌术后内分泌药物对肿瘤标志物及子宫内膜的影响。方法回顾性选取2018年11月至2022年3月长治医学院附属和平医院收治的88例乳腺癌内分泌治疗患者为研究对象,44例采用口服枸橼酸他莫昔芬片治疗的患者作为研究组,44例采用口服阿那曲唑片治疗的患者作为对照组,两组均连续用药12个月。比较两组治疗前和治疗后12个月时肿瘤标志物水平、子宫内膜厚度和药物安全性。结果两组治疗12个月后血清癌胚抗原(CEA)、糖类抗原125(CA125)、糖链抗原15-3(CA15-3)水平均较治疗前降低(P<0.05),并且研究组治疗后CEA、CA125、CA153水平低于对照组[(3.01±0.23)μg/L比(3.89±1.15)μg/L、(4.22±1.21)kU/L比(7.38±2.19)kU/L、(16.76±2.19)kU/L比(19.87±2.21)kU/L],差异有统计学意义(P<0.05)。研究组治疗后6、12个月子宫内膜厚度高于对照组[(7.23±0.22)mm比(6.21±0.19)mm、(7.98±0.24)mm比(6.47±0.22)mm],差异有统计学意义(P<0.05)。研究组治疗后12个月癌症治疗功能评价量表(FACT-G)各项维度评分均高于对照组,差异有统计学意义(P<0.05)。两组患者治疗不良反应发生情况比较差异无统计学意义(P>0.05)。结论枸橼酸他莫昔芬片可有效抑制患者血清肿瘤标志物水平,提高患者生命质量,阿那曲唑片可以明显降低乳腺癌患者子宫内膜厚度。

Objective To investigate the effects of endocrine drugs on tumor markers and endometrium after breast cancer surgery.Methods Eighty-eight patients with endocrine therapy for breast cancer admitted to the Heping Hospital Affiliated to Changzhi Medical College from November 2018 to March 2022 were selected,44 patients taken orally tamoxifen citrate tablets were enrolled in the study group,44 patients taken orally anastrozole tablets were enrolled in the control group,the patients in the two groups were treated for 12 months.The tumor markers,endometrial thickness were compared between the two groups before treatment and 12 months after treatment.The drug safety was compared too.Results After treatment,the serum levels of carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)and glycochain antigen 15-3(CA15-3)in both groups were decreased,and the level of tumor markers in the study group were lower than those in the control group:(3.01±0.23)μg/L vs.(3.89±1.15)μg/L,(4.22±1.21)kU/L vs.(7.38±2.19)kU/L,(16.76±2.19)kU/L vs.(19.87±2.21)kU/L,there were statistical differences(P<0.05).The endometrial thickness in the study group at 6 months and 12 months after treatment were higher than those in the control group:(7.23±0.22)mm vs.(6.21±0.19)mm,(7.98±0.24)mm vs.(6.47±0.22)mm,there were statistical differences(P<0.05).At 12 months after treatment,the scores of functional dimension,emotional dimension,social/family dimension and physical dimension in functional assessment of cancer therapy(FACT-G)scale in the study group were significantly higher than those in the control group(P<0.05).There was no statistically significant difference in adverse reactions between the two groups(P>0.05).Conclusions Tamoxifen citrate tablets can effectively inhibit the levels of serum tumor markers and improve the quality of life of patients,and anastrozole tablets can significantly reduce the endometrial thickness of breast cancer patients.