摘要
Reactive oxygen species(RoS)are essential for biological processes like cell signaling and chemical processes like organic oxidation.Moreover,the sufficient generation of RoS plays a significant role in targeted tumor treatments or oxidation of organics.Herein,a hydrazone-linked porphyrin covalent organic framework(Por-DETH-COF)is developed for red light-induced generation of ROS like singlet oxygen(^(1)O_(2))or superoxide(O_(2)·^(-))to undertake different but targeted oxidations.First,^(1)O_(2)is adopted in photodynamic therapy(PDT)for the oxidation of glioma cells.The PDT efficiency of Por-DETH-COF on the apoptosis of glioma cells is explored through flow cytometry and western blot assay.The apoptosis rate of glioma cells significantly increases over Por-DETH-COF under 660nm red light illumination,suggestive of the potency of^(1)O_(2).Second,O_(2)^(·-)is employed for the targeted oxidation of thiols.A series of thiols could be efficiently oxidized to corresponding disulfides over Por-DETH-COF under 660 nm red light illumination,indicative of the significance of O_(2)^(·-).This work highlights the potential of covalent organic frameworks in generating Ros for precise medical applications of complex chemical environments.
基金
supported by the National Natural Science Foundation of China(No.22072108).