深圳市妊娠期高血压疾病专病队列设计及建设概况

Overview of design and construction of hypertensive disorders of a pregnancy-cohort in Shenzhen

妊娠期高血压疾病(HDP)涉及母婴安全和重大慢性病防控两大公共卫生问题。HDP严重威胁母胎安全,是全球孕产妇和围产儿发病率及死亡率的主要原因之一,也是增加母子心血管疾病(CVD)远期风险的重要危险因素。为探索降低HDP发病风险和CVD源头防控的有效策略,本研究团队建立了基于CVD“零级预防”的深圳市HDP专病队列。目前,深圳市HDP专病队列建设已取得初步成效,HDP专病队列已招募2 239例HDP患者,已建立与之相关的数据管理平台和生物样本库,并启动了对HDP专病队列受试者产后心血管代谢疾病发病风险的随访和评估。为后续深入探讨HDP病理生理机制,尤其是子痫前期发病机制和精准分型,对子痫前期进行早期预测与预防,降低不良妊娠结局发生风险,探索HDP与母子心血管代谢疾病发病风险的相关性及防控策略,促进母子心血管健康奠定了坚实基础。

Hypertensive disorder of pregnancy(HDP)involves two major public health issues:mother-infant safety and prevention and controlling major chronic disease.HDP poses a serious threat to maternal and neonatal safety,and it is one of the leading causes of maternal and perinatal morbidity and mortality worldwide,as well as an important risk factor for long-term cardiovascular disease(CVD).In order to explore effective strategies to prevent and control the source of CVD and reduce its risk,we have established a cohort of HDPs in Shenzhen for the primordial prevention of CVD.The construction of the HDP cohort has already achieved preliminary progress till now.A total of 2239 HDP women have been recruited in the HDP cohort.We have established a cohort data management platform and Biobank.The follow-up and assessment of postpartum cardiovascular metabolic risk in this cohort has also been launched.Our efforts will help explore the pathophysiological mechanism of HDP,especially the pathogenesis and precision phenotyping,prediction,and prevention of pre-eclampsia,which,therefore,may reduce the risk of adverse pregnancy outcomes,and provide a bridge to linking HDP and maternal-neonatal cardiovascular,metabolic risk to promote the cardiovascular health of mothers and their infants.