糖酵解及其关键限速酶在急性肺损伤中的研究进展

Advances in glycolysis and its key rate-limiting enzymes in acute lung injury

急性肺损伤是一种以肺部炎症和微血管通透性增加为特征的临床综合征,但其发生机制尚未阐明.糖酵解及其关键限速酶己糖激酶、磷酸果糖激酶1和丙酮酸激酶M2,以及间接限速酶6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶3,均被认为参与了急性肺损伤的发生.本文总结糖酵解相关限速酶在急性肺损伤中的病理生理特征及其相关性,通过抑制糖酵解相关限速酶抑制糖酵解可缓解急性肺损伤.因此,靶向糖酵解相关限速酶开发急性肺损伤治疗药物具有极大的临床意义.

Acute lung injury is a clinical syndrome characterized by pulmonary inflammation and increased microvascular permeability,but the mechanism of its occurrence is still unclear.Glycolysis and its key rate-limiting enzymes hexokinase,phosphofructokinase 1,and pyruvate kinase M2,as well as the indirect rate-limiting enzyme 6-phosphofructose-2-kinase/fructose-2,6-biphosphatase 3,are thought to be involved in the development of acute lung injury.This article summarizes the pathophysiological characteristics and correlation of glycolysis related rate-limiting enzymes in acute lung injury.Inhibition of glycolysis can alleviate acute lung injury by inhibiting glycolysis related rate-limiting enzymes.Therefore,it is of great clinical significance to develop therapeutic drugs for acute lung injury by targeting rate-limiting enzymes related to glycolysis.