外周血液指标与卵圆孔未闭相关性疾病的关系

Relationship between peripheral blood parameters and diseases related to patent oval foramen

卵圆孔未闭是常见的先天性心脏疾病,且与多种疾病有关,包括隐源性脑卒中、偏头痛、减压病、低氧血症等。其中,PFO导致的隐源性卒中和偏头痛最为常见,也是目前研究最多的。近年来,外周血液指标在多种疾病的发生发展、病情严重程度及预后方面均具有潜在应用价值。PFO相关性疾病因特殊的解剖关系,其发生发展的分子机制和严重程度与血液指标的变化密切相关。本文系统地探讨了外周血液指标与PFO相关疾病的关系。本文总结发现:血小板作为血栓形成的基石可以在PFO相关性CS和偏头痛中有重要作用;MPV和MCHC的变化可能与PFO相关性偏头痛有关;NLR、PLR、TG/HDL-C、LDL-C/HDL-C与PFO相关性CS呈正相关。本文旨在为PFO相关性疾病的预防与治疗提供参考。

Patent foramen ovale(PFO)is a common congenital heart disease associated with a variety of diseases,including cryptogenic stroke,migraine,decompression sickness and hypoxemia.Cryptogenic stroke and migraine caused by PFO are the most common and well researched.Currently,clinical diagnosis of PFO is mainly based on ultrasound imaging,but the equipment and technicians are highly required.In recent years,peripheral blood indexes have potential application value in the occurrence,development,severity and prognosis of many diseases.In this paper,we reviewed the studies on the relationship between blood related indexes and PFO related diseases in order to provide reference for clinical treatment.