基于网络药理学的积雪草酸治疗IA1期宫颈癌治疗机制的研究

The Mechanistic of Asiatic Acid in the Treatment of Stage Ia1 Cervical Cancer Based on Network Pharmacology

通过网络药理学方法筛选获得积雪草酸与IA1期宫颈癌的交集靶点,分析GO功能和信号通路,经拓扑学筛选核心靶点,进行分子对接验证。结果表明,积雪草酸与IA1期宫颈癌有60个交集靶点,涉及101项GO功能和30条KEGG信号通路,确定了4个核心靶点(IL1B、CXCL8、CCL2和TLR4),分子对接验证结果显示积雪草酸与核心靶点结合稳定。

The intersection targets of asiatic acid and IA1 stage cervical cancer were screened through network pharmacology methods,GO function and signaling pathways were analyzed,and the core targets were screened through topology for molecular docking verification.The results showed that there were 60 intersecting targets between asiatic acid and stage IA1 cervical cancer,involving 101 GO functions and 30 KEGG signaling pathways.Four core targets(IL1B,CXCL8,CCL2,and TLR4)were identified,and molecular docking verification results showed stable binding between asiatic acid and the core targets.