叶酸联合维生素B_(12)辅助治疗对H型高血压的临床疗效及血管内皮功能的影响

Clinical Efficacy on H-type Hypertension and Effect on Vascular Endothelial Function of Folic Acid Combined with Vitamin B_(12) Adjuvant Therapy

目的:探索叶酸联合维生素B_(12)辅助治疗对H型高血压患者的临床疗效及血管内皮细胞功能的影响。方法:采用随机对照试验方法,纳入2020年4月—2022年4月在江南大学附属医院就诊的70例H型高血压患者为研究对象。采用简单随机抽样方法,将患者随机分为观察组和对照组各35例。对照组接受苯磺酸氨氯地平片治疗,观察组在此基础上加用叶酸和维生素B_(12),两组患者均进行为期12周的干预。观察两组患者干预前后血压值、血清同型半胱氨酸(Hcy)、内皮素-1(ET-1)、血管内皮生长因子(VEGF)、白细胞介素-6(6IL-6)、超敏C反应蛋白(hs-CRP)水平变化。结果:叶酸联合维生素B_(12)辅助治疗H型高血压患者,相比于单纯降压药治疗,降压效果更好(91.43%vs71.43%,P<0.05),可更好地降低血清Hcy水平[(8.93±2.19)vs(15.87±3.74)μmol/L],且可更好地控制血清IL-6、hs-CRP、ET-1、VEGF水平,差异均具有统计学意义(P<0.05)。结论:在H型高血压患者临床实际治疗中,可增加叶酸及维生素B_(12)辅助治疗。

【Objective】To explore the effect of folic acid combined with vitamin B12 adjuvant therapy on clinical efficacy and vascular endothelial cell function in patients with H-type hypertension.【Method】A randomized controlled trial method was used to include 70 patients with H-type hypertension who attended the Affiliated Hospital of Jiangnan University from April 2020 to April 2022 as study subjects.A simple random sampling method was used to randomly divide the patients into 35 cases each in the observation group and the control group.The control group received amlodipine benzoate tablets,and the observation group added folic acid and vitamin B12 on top of the next,and both groups underwent the intervention for 12 weeks.Changes in blood pressure,serum homocysteine(Hcy),endothelin-1(ET-1),vascular endothelial growth factor(VEGF),interleukin-6(IL-6)and hypersensitive C-reactive protein(hs-CRP)levels were observed in both groups before and after the intervention.【Result】Folic acid combined with vitamin B12 adjuvant therapy in patients with Htype hypertension showed better antihypertensive effect compared with antihypertensive drugs alone(91.43%vs 71.43%,P<0.05),could better reduce serum Hcy levels[(8.93±2.19)vs(15.87±3.74)μmol/L],and could better control serum IL-6,hs-CRP,ET-1 and VEGF levels,all with statistically significant differences(P<0.05).【Conclusion】In the actual clinical treatment of patients with H-type hypertension,folic acid and vitamin B12 can be added as adjuvant therapy.