手性硫化铜纳米颗粒的制备及其近红外抗菌性能

Synthesis of Chiral CuS Nanoparticles and Their Near-Infrared-Activated Antibacterial Properties

成功制备了手性硫化铜纳米颗粒(CuS NP),并对其光热、近红外抗菌性能进行了研究,分析了手性CuS NP的近红外抗菌机理。结果表明,在溶液浓度、近红外光照时间等条件相同的情况下,在波长为808 nm、功率密度为2 W·cm^(-2)的近红外激光照射下,手性CuS NP可在250 s内升温至38℃左右,在升温速度和最终温度方面的表现均优于非手性CuS NP,并且在近红外光照射6 min后抑菌率便可达到100%,具有更好的抗菌效果。手性CuS NP对近红外光的高吸收率可以解释其良好的光热响应性能。而其表面手性配体对细菌细胞膜的亲和性使得手性CuS NP更容易被细菌内吞,从而实现高效的近红外抗菌。在模拟口罩外表面抗菌的情境中,手性CuS NP在近红外光照射8 min后可以达到完全灭菌的效果,亦表现出高效、快速的近红外抗菌性能。这一研究为手性CuS NP在抗菌领域的应用提供了新的思路和实验基础。

Chiral CuS nanoparticles(NPs)were successfully synthesized and their photothermal properties and near-infrared-activated antibacterial performances were investigated.The nearinfrared(NIR)-activated antibacterial mechanism of chiral CuS NPs was further analyzed.The results show that under the same conditions including solution concentration and near-infrared irradiation time,the temperature of chiral CuS NPs can reach up to about 38℃within 250 s under the irradiation of near-infrared laser with wavelength of 808 nm and power density of 2 W·cm-2,showing better performance in terms of temperature-rising velocity and final temperature compared with achiral CuS NPs.And after 6 min of near-infrared light irradiation,the antibacterial rate of the chiral CuS NPs can reach 100%,which has a better antibacterial effect.The high absorption rate of the chiral CuS NPs to near-infrared light can explain its good photothermal response.The affinity of chiral ligands to bacterial cell membranes makes chiral CuS NPs easier to be endocytosed by bacteria,thus achieving efficient near-infrared-activated antibacterial activity.In the simulated antibacterial situation of the outer surface of the mask,the chiral CuS NPs can achieve complete sterilization effect after 8 min irradiation with near-infrared light,and also show efficient and rapid near-infrared-activated antibacterial performance.The study provides a new idea and experimental basis for the application of chiral CuS NPs in antibacterial field.