发动蛋白抑制剂dynasore的功能及在疾病治疗中的研究进展

Progress in function of dynamin inhibitor dynasore and its role involved in treatments of diseases

发动蛋白(dynamin)超家族存在于所有细胞生命活动中,在胞膜构成、肌动蛋白束和先天免疫等方面发挥重要作用。发动蛋白作为该家族的主要成员,是一种多结构域的机械化学鸟苷三磷酸酶(guanosine triphosphatase,GTPase)蛋白,对鸟嘌呤核苷酸具有低亲和力、高基础水解率,能自组装成高阶螺旋结构^([1]),在包膜重塑、膜裂变和跨高尔基体出芽等作用中发挥着重要作用^([2])。

Dynasore is a small molecule that inhibits the GTPase activity of dynamin and mitochondria-related proteins both in vitro and in vivo,consequently preventing bacteria and viruses from entering cells via endocytic processes,impeding infection and spread of the pathogen.Dynasore is able to participate in cell survival,proliferation and apoptosis through a variety of dynamin protein-independent mechanisms such as reducing reactive oxygen species production,inhibiting ferroptosis,lowering dynamin-related protein 1 activity to reduce mitophagy,and deeply engaging in vascular endothelial growth factor pathway.Here based on the molecular mechanisms and signaling pathways of dynasore involving in diseases,this review summarizes the role of dynasore in microbial infections,neurodegenerative diseases,and tumors.