β-arrestin2在心血管疾病中的研究进展

Research progress ofβ-arrestin2 in cardiovascular disease

β-抑制蛋白2(β-arrestin2)是一类具有多种生物学功能的细胞内蛋白质,不仅能够通过与G蛋白竞争性结合G蛋白偶联受体(G protein-coupled receptor,GPCR)从而负性调控GPCR信号通路,还可通过G蛋白非依赖性途径参与调节多种信号转导通路,对心血管系统的稳定至关重要。此外,β-arrestin2异常的表达与高血压、心力衰竭、心肌缺血再灌注损伤、心室重塑、动脉粥样硬化以及动脉瘤等多种疾病密切相关。因此,本文就β-arrestin2在心血管疾病领域的研究进展进行综述,阐述β-arrestin2结构、功能及其在炎症反应、细胞代谢中的作用和相关分子机制,以期为心血管疾病诊治提供新的思路。

β-arrestin2 is a kind of intracellular protein with multiple biological functions.It can not only negatively regulate GPCR signal pathway by competitively binding to G protein-coupled receptor(GPCR)with G protein,but also participate in regulating multiple signal transduction pathways through G protein independent pathways,which is critical to the stability of cardiovascular system.In addition,the abnormal expression ofβ-arrestin2 is associated with hypertension,heart failure,myocardial ischemia-reperfusion injury,ventricular remodeling,arteriosclerosis and aneurysm.This paper introduces the research progress ofβ-arrestin2 in the field of cardiovascular disease,and expounds the structure,function,role and related molecular mechanism ofβ-arrestin2 in inflammatory reaction and cell metabolism,aiming to provide new ideas and methods for the prevention and treatment of cardiovascular diseases.