脱氢表雄酮调节炎性细胞因子作用的研究进展

Research progress on the role of DHEA in regulating inflammatory cytokines

炎症性疾病通常由过度或持续的炎症反应所引起。炎性细胞因子参与了炎症反应中的多个过程,如促进炎症细胞的聚集、诱导炎症介质的生成等。因此,控制炎性细胞因子的生成对炎症性疾病的治疗具有至关重要的作用。脱氢表雄酮(dehydroepiandrosterone,DHEA)是一种内源性类固醇激素。DHEA能调节炎性细胞因子的产生和释放,具有控制炎症反应的潜力。本文从DHEA的特征、调节炎性细胞因子的机制及临床应用前景进行综述,为临床治疗炎症性疾病提供新的思路和策略。

Inflammatory diseases are usually caused by an excessive or persistent inflammatory response.Inflammatory cytokines are involved in several processes in the inflammatory response,such as promoting the aggregation of inflammatory cells and inducing the production of inflammatory mediators.Controlling the production of inflammatory cytokines is therefore crucial to the treatment of inflammatory diseases.Dehydroepiandrosterone(DHEA)is an endogenous steroid hormone.DHEA regulates the production and release of inflammatory cytokines and has the potential to control the inflammatory response.This paper reviews the characteristics of DHEA,the mechanism of regulating inflammatory cytokines and the prospect of clinical application to provide new ideas and strategies for the clinical treatment of inflammatory diseases.