脂蛋白相关磷脂酶A2联合白细胞介素10对青年脑梗死患者预后的预测价值

Predictive Value of Lipoprotein-associated Phospholipase A2 Combined with Interleukin-10 in the Prognosis of Young Patients with Cerebral Infarction

【目的】探讨外周血白细胞介素10(IL-10)联合脂蛋白相关磷脂酶A2(LP-PLA2)对青年脑梗死患者预后的预测价值。【方法】86例青年脑梗死患者,根据其出院后3个月的预后情况分成预后不良组与预后良好组,分析影响患者预后的危险因素。以曲线下面积(AUC)评估外周血LP-PLA2、IL-10预测青年脑梗死患者预后不良的价值。【结果】86例患者,出院后3个月发生预后不良21例,发生率为24.42%(21/86)。预后不良组患者尿酸(UA)水平低于预后良好组(P<0.05),肿瘤坏死因子-α(TNF-α)、外周血IL-10、LP-PLA2水平高于预后良好组(P<0.05)。外周血IL-10、LP-PLA2、TNF-α为影响青年脑梗死患者预后不良的危险因素(OR=3.374、3.010、2.740,均P<0.05)。外周血LP-PLA2、IL-10及二者联合预测青年脑梗死患者预后不良的AUC为0.755、0.752、0.884(P<0.05),且二者联合的AUC值更高(P<0.05)。【结论】外周血LP-PLA2、IL-10在预测青年脑梗死患者预后中具有重要价值,且二者联合具有更高的预测价值。

【Objective】To analyze the predictive value of interleukin-10(IL-10)combined with lipoprotein-associated phospholipase A2(LP-PLA2)in the prognosis of young patients with cerebral infarction.【Methods】A total of 86 young patients with cerebral infarction were recruited in the study to analyze the prognostic risk factors.According to the prognosis of 3 months after discharge,the patients were divided into the poor prognosis group and good prognosis group.The value of peripheral blood LP-PLA2 and IL-10 in predicting prognosis of young patients with cerebral infarction was investigated by area under the curve(AUC).【Results】Among 86 young patients with cerebral infarction,21 cases(24.42%)had the poor prognosis at 3 months after discharge.The level of uric acid(UA)in the poor prognosis group was lower than that in the good prognosis group(P<0.05),while the levels of tumor necrosis factor-α(TNF-α),IL-10 and LP-PLA2 of peripheral blood in the poor prognosis group were higher than those in the good prognosis group(P<0.05).IL-10,LP-PLA2 and TNF-αin peripheral blood were risk factors for the poor prognosis in young patients with cerebral infarction(OR=3.374,3.010,and 2.740,P<0.05).The AUC values of peripheral blood LP-PLA2,IL-10 and their combination in predicting poor prognosis of young patients with cerebral infarction were 0.755,0.752 and 0.884(P<0.05),respectively,which showed the AUC value of the combination of LP-PLA2 and IL-10 were higher(P<0.05).【Conclusion】Peripheral blood LP-PLA2 and IL-10 play an important role in predicting the prognosis of young patients with cerebral infarction,and their combination has even higher predictive value.