豁痰息痉汤联合溶栓治疗急性脑梗死患者的疗效及对脑血流动力学的影响

Efficacy of Huotan Xijing Tang Combined with Thrombolysis on Patients with Acute Cerebral Infarction and Effect on Cerebral Hemodynamics

【目的】探讨豁痰息痉汤联合溶栓治疗急性脑梗死的疗效及对患者脑血流动力学的影响。【方法】108例急性脑梗死患者,随机分为观察组和对照组,每组54例。对照组采用溶栓治疗,观察组采用豁痰息痉汤联合溶栓治疗,比较两组疗效和不良反应及治疗前后患者相关指标的差异。【结果】观察组治疗总有效率为94.44%(51/54),明显高于对照组的81.48%(44/54),且差异有统计学意义(P<0.05)。治疗后,两组突然昏仆、半身不遂、口舌歪斜等中医证候评分均低于治疗前(P<0.05),且观察组低于对照组(P<0.05)。治疗后,两组神经功能量表(NIHSS)评分明显低于治疗前,蒙特利尔认知评估量表(MoCA)评分、日常生活能力量表(ADL)评分均高于治疗前(P<0.05),且观察组各项评分改善优于对照组(P<0.05)。治疗后,两组患者搏动指数(PI)低于治疗前,双侧大脑中动脉的峰流速(V_(P))、平均血流速度(V_(m))高于治疗前(P<0.05),且观察组各项指标改善优于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】豁痰息痉汤联合溶栓治疗急性脑梗死患者能明显提高疗效,降低中医症状评分,改善患者神经功能、脑血流动力学,提高患者认知功能及日常生活能力,且药物不良反应发生率较小。

【Objective】To investigate the therapeutic effect of Huotan Xijing Tang combined with thrombolysis on patients with acute cerebral infarction and its impact on cognitive function and cerebral hemodynamics.【Methods】A total of 108 patients with acute cerebral infarction were randomly divided into an observation group and a control group,with 54 cases in each group.The control group was treated with thrombolysis,while the observation group received Huotan Xijing Tang combined with thrombolysis.The therapeutic effects,adverse reactions,and differences in related indicators before and after treatment were compared between the two groups.【Results】The overall effectiveness rate of the observation group was 94.44%(51/54),which was significantly higher than the 81.48%(44/54)of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores for Traditional Chinese Medicine(TCM)symptoms such as sudden fainting,hemiplegia,and deviation of the mouth and tongue were lower in both groups compared to before treatment(P<0.05).Moreover,the observation group had a greater reduction in these scores than the control group(P<0.05).After treatment,the National Institutes of Health Stroke Scale(NIHSS)scores in both groups significantly reduced,and the Montreal Cognitive Assessment(MoCA)scores and Activities of Daily Living(ADL)scores increased compared to before treatment(P<0.05).The improvement in scores of the observation group was better than that of the control group(P<0.05).After treatment,the pulsatility index(PI)levels in both groups were lower than before treatment,and the peak flow velocity(V_(P))and mean flow velocity(V_(m))levels of the bilateral middle cerebral artery were higher than before treatment(P<0.05).The improvement in these parameters of the observation group was better than that of the control group(P<0.05).The overall incidence of adverse reactions between the two groups showed no statistically significant difference(P>0.05).【Conclusion】Huotan Xijing Tang combined with thrombolysis in patients with acute cerebral infarction can significantly improve therapeutic effects,reduce TCM symptom scores,enhance neural function,improve cerebral hemodynamics,and elevate patients'cognitive function and daily living ability with minimal drug adverse reactions.