血清孕酮、β-HCG联合检测对早期先兆流产的诊断价值

Serum Progesterone β-Analysis of the Diagnostic Value of Combined HCG Detection for Early Threatened Abortion

目的分析血清孕酮、β-人绒毛膜促性腺激素(β-humanchorionic gonadotrophin,β-HCG)联合检测诊断早期先兆流产的效能。方法选取2021年5月—2023年5月酒钢医院收治的92例早期先兆流产患者纳入观察组,另将同期于酒钢医院检查的88例正常妊娠孕妇纳入对照组。研究对象入组后,次日采集其空腹5 mL静脉血,检测对比两组间孕酮、β-HCG的差异;另描绘受试者工作特征曲线(receiver operating characteristic curve,ROC),分析孕酮、β-HCG单独及联合检测诊断早期先兆流产的效能。结果观察组孕酮为(25.31±2.49)ng/m L、β-HCG为(14235.88±301.26)mIU/mL,低于对照组的(32.87±3.24)ng/mL、(17897.69±326.54)mIU/mL,差异有统计学意义(P<0.05)。ROC结果显示孕酮、β-HCG联合检测诊断早期先兆流产的ROC曲线下面积(area under curve,AUC)为0.935(95%CI 0.899~0972,敏感度为100%,特异度为84.10%),高于孕酮单独诊断的0.853(95%CI0.797~0.908,敏感度为90.20%,特异度为70.50%)、β-HCG单独诊断的0.855(95%CI0.802~0.909,敏感度为98.90%,特异度为61.40%)。结论早期先兆流产患者机体内的孕酮、β-HCG处于较低水平,孕酮、β-HCG联合检测能够有效诊断出该病。本研究结果为临床提供一定的借鉴内容,具有一定的诊断价值。

Objective To analyze serum progesteroneβ-humanchorionic gonadotrophin(β-humanchorionic gonadotrophin,β-HCG)combined detection in diagnosing early threatened miscarriage.Methods A total of 92 patients with early threatened abortion who were admitted to Jiugang Hospital from May 2021 to May 2023 were included in the observation group,and 88 normal pregnant women who were examined in Jiugang Hospital during the same period were included in the control group.After the study subjects were included in the group,their fasting 5 mL venous blood was collected the next day,and progesteroneβ-Differences in HCG.Describe the receiver operating characteristic curve receiver operating characteristic curve(ROC)of the subjects and analyze progesteroneβ-the efficacy of HCG alone and in combination in diagnosing early threatened miscarriage.Results The progesterone concentration in the observation group was(25.31±2.49)ng/mL,β-HCG was(14235.88±301.26)mIU/mL,which was lower than the control group's(32.87±3.24)ng/mL and(17897.69±326.54)mIU/mL,with a statistical difference(P<0.05).ROC results showed that combined detection of progesterone andβ-HCG in the diagnosis of early threatened abortion was 0.935(95%CI 0.899-0972,sensitivity 100%,specificity was 84.10%),which was higher than the 0.853(95%CI0.797-0.908,sensitivity was 90.20%,specificity was 70.50%)diagnosed with progesterone aloneβ-The individual diagnosis of HCG was 0.855(95%CI 0.802-0.909,sensitivity was 98.90%,specificity was 61.40%).Conclusion Progesterone levels in the body of patients with early threatened miscarriageβ-HCG is at a low level,combined detection of progesterone andβ-HCG can effectively diagnose this disease.The research results in this article provide certain reference content for clinical practice,and have certain diagnostic value.