铜死亡在鼻咽癌治疗中的作用研究进展

Research progress on cuprotosis in nasopharyngeal carcinoma

鼻咽癌(NPC)是我国多发恶性肿瘤,约四分之三的患者诊断时已为局部晚期。放疗和全身化疗是目前NPC患者的重要治疗方法,患者预后情况不容乐观。因此,改善NPC患者的预后是目前临床上亟待解决的问题。最近,一项最新研究发现了一种新的调节性细胞死亡方式铜死亡,它在一定程度上降低了肿瘤治疗中的耐药性,对肿瘤的防治具有巨大的潜能。因此,本文将展开阐述铜死亡抗肿瘤的作用机制及在NPC治疗中的作用研究进展,为NPC患者的治疗提供新的依据。

Nasopharyngeal carcinoma(NPC)is a highly occurring malignant tumor in China,and about three-quarters of patients are diagnosed with local advanced stage.Radiotherapy and systemic chemotherapy are currently important treatments for patients with NPC,and the prognosis of patients is not optimistic.Therefore,improving the prognosis of NPC patients is an urgent problem to be solved clinically.Recently,the latest research has found that a new regulatory cell death mode cuprotosis,which has reduced drug resistance in tumor treatment to a certain extent,and which possesses great potential in tumor prevention and treatment.Therefore,this paper will summarize the activation mechanism of cuprotosis-related anti-cancer and its research progress in NPC,which provides a new basis for NPC treatment.