脂肪来源的间充质干细胞治疗变应性鼻炎的研究进展

Research progress of adipose-derived mesenchymal stem cells in the treatment of allergic rhinitis

变应性鼻炎(AR)是机体经变应原诱发产生的常见良性变态反应性疾病。除了与过敏相关的鼻部和眼部症状外,还会导致睡眠质量下降,白天生活质量降低等问题,影响患者的工作和生活。目前AR的治疗方法是以远离变应原及药物控制为主,且在疗效上有其局限性和弊端。干细胞疗法的应用在各疾病的治疗中正在得到极大地发展。脂肪来源的间充质干细胞(MSCs)因其独特的免疫调节及抗炎等作用以及获取方便等优势,在AR的治疗上具有相当的潜力。本文就脂肪来源MSCs治疗AR的实验研究进展作一综述。

Allergic rhinitis(AR)is a common benign allergic disease induced by allergens.In addition to the nasal and ocular symptoms associated with allergies,it can also lead to problems such as decreased sleep quality and daytime quality of life,affecting the patients’work and life.At present,the treatment methods of AR are mainly far away from allergens and drug control,which are limited,and disadvantages in terms of efficacy.The application of stem cell therapy is being greatly developed in the treatment of various diseases.Adipose-derived mesenchymal stem cells(MSCs)have considerable potential in the treatment of AR due to their unique immunomodulatory and anti-inflammatory effects,as well as the advantages of convenient access.This paper reviews the progress of experimental research on adipose-derived MSCs in the treatment of AR.