抑郁障碍患者静息态功能连接强度研究

Resting-state functional connectivity strength in patients with major depressive disorder

目的探讨静息状态下抑郁障碍患者脑网络功能连接特征和强度。方法纳入抑郁障碍患者(抑郁障碍组)和健康被试(对照组),进行静息态功能磁共振(resting state functional magnetic resonance imaging,rs-fMRI)扫描。计算两组被试全脑度中心性(degree centrality,DC)值,进而计算其功能连接强度;采用支持向量机(support vector machine,SVM)方法探索异常的DC值是否对抑郁障碍有识别作用。结果抑郁障碍组26例患者和对照组37名对照纳入分析。相较于对照组,抑郁障碍组左侧额中回DC值降低(t=-4.98,P<0.05,GRF校正),而右侧颞中回(t=5.02,P<0.05,GRF校正)、右侧海马旁回(t=4.80,P<0.05,GRF校正)、右侧小脑后部(t=4.98,P<0.05,GRF校正)DC值增加。抑郁障碍组异常脑区DC值与17项-汉密尔顿抑郁量表、贝克抑郁量表得分无统计学相关性(P>0.05)。SVM分析结果显示,左侧额中回DC值降低区分抑郁障碍组和对照组的准确度为84.13%,敏感度为88.46%,特异度为81.08%,受试者操作特征曲线下面积为0.87。结论静息状态下抑郁障碍患者左侧额中回及右侧颞中回、右侧海马旁回、右侧小脑后部存在功能连接改变,左侧额中回功能连接强度变化可能对抑郁障碍的识别有提示作用。

Objective To explore the functional connectivity characteristics and intensity of brain network in depression at rest.Methods Patients with major depressive disorder(MDD)and healthy controls(HCs)underwent resting state functional magnetic resonance imaging.The total brain degree centrality(DC)of the two groups was calculated to assess the functional connection strength.Support vector machine(SVM)method was used to investigate whether abnormal DC value can recognize MDD.Results A total of 26 patients and 37 controls were included in the analysis.Compared to HCs,MDD group showed decreased DC value in the left middle frontal gyrus(t=-4.98,P<0.05,GRF corrected)and increased DC value in the right middle temporal gyrus(t=5.02,P<0.05,GRF corrected),right parahippocampal gyrus(t=4.80,P<0.05,GRF corrected),and right posterior cerebellar gyrus(t=4.98,P<0.05,GRF corrected).Additionally,no significant correlations were found between abnormal DC values and clinical variables(i.e.,17-item Hamilton depression scale and Beck depression scale scores)in MDD group(P>0.05).SVM analysis showed that decreased DC value in the left middle frontal gyrus might be used to distinguish MDD group from HCs with an accuracy of 84.13%,a specificity of 81.08%,and a sensitivity of 88.46%,the area under the operational characteristic curve is 0.87.Conclusions Altered DC values in the left middle frontal gyrus and right middle temporal gyrus,right parahippocampal gyrus,right posterior cerebellum may contribute to the pathophysiology of MDD.The change of functional connection strength of the left medial frontal gyrus may be helpful for the recognition of MDD.