童年期创伤与抑郁症患者血浆脂联素水平关联研究

Association between childhood trauma and plasma adiponectin levels in patients with depression

目的探讨童年期创伤与抑郁症患者血浆脂联素水平的相关性。方法纳入抑郁症患者121例,健康对照39名(对照组)。采用童年期创伤问卷(childhood trauma questionnaire,CTQ-SF)评估童年期虐待和忽视经历,根据CTQ-SF评分将抑郁症患者分为创伤组(n=53)和无创伤组(n=68)。采用17项汉密尔顿抑郁量表(Hamilton depression scale-17,HAMD_(17))和汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)分别评定患者的抑郁、焦虑症状严重程度。采用酶联免疫吸附法测定受试者的血浆脂联素水平。结果创伤组的血浆脂联素水平[3.82(2.44,4.92)μg/mL]低于无创伤组[4.64(2.98,6.43)μg/mL,P=0.01]和对照组[6.29(4.54,7.51)μg/mL,P<0.01],无创伤组的血浆脂联素水平低于对照组(P<0.01)。相关分析显示抑郁症患者血浆脂联素水平与童年期创伤呈负相关(r=-0.34,P<0.01)。多因素线性回归分析表明,抑郁症患者的血浆脂联素水平与童年期创伤得分呈负关联(β=-0.05,P<0.01)。结论经历过童年期创伤的抑郁症患者具有更低的血浆脂联素水平,抑郁症患者血浆脂联素水平下降可能与童年期创伤有关。

Objective To explore the correlation between childhood trauma and plasma adiponectin levels in patients with depression.Methods A total of 121 patients with depression and 39 healthy controls(control group)were enrolled.Childhood trauma questionnaire(CTQ-SF)was used to assess the experience of childhood abuse and neglect,and the patients with depression were divided into trauma group(n=53)and non-trauma group(n=68)according to the CTQ-SF score.The 17-item Hamilton depression scale-17(HAMD_(17))and the Hamilton anxiety scale(HAMA)were used to evaluate the severity of depression and anxiety symptoms,respectively.Plasma adiponectin levels of subjects were measured by enzyme-linked immunosorbent assay.Results The plasma adiponectin level of trauma group[3.82(2.44,4.92)μg/mL]was significantly lower than that of non-trauma group[4.64(2.98,6.43)μg/mL,P=0.01]and the control group[6.29(4.54,7.51)μg/mL,P<0.01].The plasma adiponectin level of non-trauma group was lower than that of the control group(P<0.01).Correlation analysis showed that plasma adiponectin level in patients with depression was negatively correlated with childhood trauma(r=-0.34,P<0.01).Multivariate linear regression analysis showed that plasma adiponectin level was negatively correlated with childhood trauma scores in patients with depression(β=-0.05,P<0.01).Conclusions Patients with depression who have experienced childhood trauma have lower plasma levels of adiponectin,and childhood trauma may be associated with decreased plasma adiponectin levels in patients with depression.